| Specific accumulation of CYP94A1 transcripts after exposure to gaseous benzaldehyde: Induction of lauric acid ω-hydroxylase activity in Vicia sativa exposed to atmospheric pollutants. | |
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MedLine Citation:
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PMID: 21035797 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The effects of air pollutants such as aldehydes, ozone, nitrogen dioxide and benzene on fatty acid ω-hydroxylase activity in Vicia sativa microsomes have been investigated. Four days old etiolated V. sativa seedlings were exposed to different concentrations of selected pollutants for varying exposure times. Growing etiolated V. sativa seedlings in air containing the gaseous benzaldehyde (150nM) led to an 8-fold enhancement of lauric acid ω-hydroxylase activity in microsomes of treated plants compared to controls grown in pure air (96±10 versus 12±2pmol/min/mg protein, respectively). The induction increased with increasing gas phase concentrations (10-1300nM) and the maximum of activity was measured after 48h of exposure. Northern blot analysis revealed that this induction occurred via transcriptional activation of the gene coding for CYP94A1. The absence of CYP94A2 and CYP94A3 transcription activation together with the missing effect on epoxide hydrolases activities indicate the specificity of CYP94A1 induction by benzaldehyde. Exposure to nitrogen dioxide, ozone and formaldehyde also stimulated lauric acid ω-hydroxylases activity while exposure to benzene did not show any effect. |
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Authors:
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P E Kastner; S Le Calvé; L Diss; V Sauveplane; R Franke; L Schreiber; F Pinot |
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Publication Detail:
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Type: Journal Article Date: 2010-10-30 |
Journal Detail:
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Title: Environmental research Volume: 111 ISSN: 1096-0953 ISO Abbreviation: Environ. Res. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0147621 Medline TA: Environ Res Country: United States |
Other Details:
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Languages: eng Pagination: 37-44 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Institut de Biologie Moléculaire des Plantes, CNRS - Université de Strasbourg IBMP-UPR 2357, Département Réseaux Métaboliques, 28 rue Goethe, F-67083 Strasbourg Cedex, France; Laboratoire des Matériaux, Surfaces et Procédés pour la Catalyse (LMSPC)/CNRS and Université de Strasbourg, 25 rue Becquerel, 67087 Strasbourg Cedex 02, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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