| Specific IgE to food and inhalant allergens in intestinal washings of children affected by atopic eczema. | |
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MedLine Citation:
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PMID: 4028388 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serum and rectal total and specific IgE were measured in eleven children with atopic dermatitis and eight with atopic dermatitis and associated wheezing. Specific IgE to food and inhalant allergens in rectal washings were found in fourteen patients. Of the seventy-six allergens which gave positive results, twenty were positive in both serum and intestine, thirty in serum alone and twenty-six in intestines alone. Specific intestinal IgE were confirmed by food challenge in three out of four patients whose skin-prick test and serum RAST were both negative. Local production of these antibodies was demonstrated by the 'double ratio' of Deuschl and Johansson, and the 'specific activity ratio' of Platts-Mills. Positive ratios (greater than 1) were obtained with both formulas for twelve of fourteen allergens tested. These data suggest that gut-associated lymphoid tissue may play a role in the pathogenesis of atopic disease. |
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Authors:
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F Marcucci; L G Sensi; G Bizzarri |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical allergy Volume: 15 ISSN: 0009-9090 ISO Abbreviation: Clin. Allergy Publication Date: 1985 Jul |
Date Detail:
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Created Date: 1985-10-07 Completed Date: 1985-10-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0311172 Medline TA: Clin Allergy Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 345-54 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Allergens
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immunology* Antibody Specificity Child Child, Preschool Dermatitis, Atopic / etiology, immunology* Food Hypersensitivity / immunology* Humans Immunoglobulin E / immunology* Infant Intestinal Mucosa / immunology Radioallergosorbent Test Skin Tests |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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