Document Detail

Specific IgE antibody response to human insulin in diabetic subjects.
MedLine Citation:
PMID:  8237718     Owner:  NLM     Status:  MEDLINE    
Treatment with heterologous insulin preparations induce insulin antibody formation in most of the patients. A hundred of diabetic individuals in treatment with human insulin (HI) for at least 6 months at the time of the study and without any clinical immunological reaction, were selected in order to study the development of specific IgE antibodies against HI by in vivo and in vitro methods. Serologic specific IgE antibodies to HI were measured by RAST (Pharmacia) and 5 RAST-positive subjects were found. The specificity of these results were confirmed in 4 of the 5 subjects by RAST-inhibition. Thus, the prevalence of specific serologic IgE to HI in our study was 4% (1.1%-9.9%, p < 0.05). Only two of the RAST-positive subjects had cutaneous reactivity to HI by intradermal technique and one of the RAST-negative subjects presented also insulin skin reactivity. HI skin reactivity was found in 3% (0.6%-8.5%, p < 0.05) of the 100 diabetic subjects. These results differ from others obtained with heterologous insulins.
C Marcos; J Cuesta; M Cuevas; J Balsa; J Fraj; E Alvarez-Cuesta
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Allergologia et immunopathologia     Volume:  21     ISSN:  0301-0546     ISO Abbreviation:  Allergol Immunopathol (Madr)     Publication Date:    1993 Jul-Aug
Date Detail:
Created Date:  1993-12-21     Completed Date:  1993-12-21     Revised Date:  2013-01-18    
Medline Journal Info:
Nlm Unique ID:  0370073     Medline TA:  Allergol Immunopathol (Madr)     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  141-4     Citation Subset:  IM    
Department of Allergy, Hospital Ramón y Cajal, Madrid, Spain.
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MeSH Terms
Antibodies, Anti-Idiotypic / biosynthesis*,  immunology
Antibody Specificity
Cattle / immunology
Diabetes Mellitus / drug therapy,  immunology*
Immunoglobulin E / immunology*
Insulin / classification,  immunology*,  therapeutic use
Intradermal Tests
Middle Aged
Radioallergosorbent Test
Recombinant Proteins / immunology
Species Specificity
Swine / immunology
Reg. No./Substance:
0/Antibodies, Anti-Idiotypic; 0/Insulin; 0/Recombinant Proteins; 0/anti-IgE antibodies; 37341-29-0/Immunoglobulin E

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