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Specific Activity of Electron-Beam Synthesis Immobilized Hyaluronidase on G-CSF Induced Mobilization of Bone Marrow Progenitor Cells.
MedLine Citation:
PMID:  23314929     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The effects of nanotechnology (electron-beam) -PEGylated (or immobilized; Im) hyaluronidase (HD) on the state of the pool of bone marrow progenitor cells and their mobilization induced by granulocyte colony stimulating factor (G-CSF) were studied. A high specific activity of the drug Im-HD on progenitor cells of different classes was demonstrated using parenteral and enteral administration. An increase in the content of erythroid (E), granulomonocytic (GM), fibroblast (F) colony-forming units (CFU) and mesenchymal stem cells (MSC) in bone marrow was shown, as well as G-CSF-induced stimulation of mobilization of precursors into the peripheral blood under the influence of Im-HD. The detected activity of this novel drug on progenitor cells indicates the potential for a safe and highly effective treatment for hematology practice and regenerative medicine.
Authors:
A M Dygai; G N Zyuz'kov; V V Zhdanov; E V Udut; L A Miroshnichenko; E V Simanina; T Yu Khrichkova; M Yu Minakova; P G Madonov
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-13
Journal Detail:
Title:  Stem cell reviews     Volume:  -     ISSN:  1558-6804     ISO Abbreviation:  Stem Cell Rev     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101255952     Medline TA:  Stem Cell Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Federal State Budgetary Institution, "Research Institute of Pharmacology" under the Siberian Branch of Russian Academy of Medical Sciences, Tomsk city (director - academician of RAMS A.M. Dygai), 634028, Tomsk, Lenin Avenue, 3 (Institute of Pharmacology of RAMS SB), Russia.
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