| Species-specific kinetics of mouse renin contribute to maintenance of normal blood pressure in transgenic mice with overexpressed human angiotensinogen. | |
| | |
MedLine Citation:
|
PMID: 1477169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Angiotensinogen, the precursor of a vasoactive octapeptide angiotensin II, is the only known natural substrate of renin, and its reaction exhibits strict species specificity and is the rate-limiting step in the renin-angiotensin system that controls the blood pressure. We measured blood pressure and heart rate of the transgenic mice with overproduced human angiotensinogen, and showed no significant difference in these parameters between transgenic and nontransgenic mice. We also provided evidence that mouse renin could not cleave human angiotensinogen, indicating a lack of angiotensin production from the human substrate. These results suggested that the blood pressure of transgenic mice is normally maintained, probably due to the inability of mouse renin to release angiotensin from the transgene products. |
| | |
Authors:
|
S Takahashi; A Fukamizu; T Hatae; Y Yamada; F Sugiyama; N Kajiwara; K Yagami; K Murakami |
Related Documents
:
|
6100599 - Enalapril (mk421) in the treatment of hypertension with renal artery stenosis. 8335229 - Reduced renal arterial perfusion pressure stimulates renin release from domestic fowl k... 18506359 - A dipeptide yy derived from royal jelly proteins inhibits renin activity. 3305039 - Postprandial changes in supine and erect heart rate, systemic blood pressure and plasma... 15748539 - Molecular evidence of tissue renin-angiotensin systems: a focus on the brain. 349389 - Role of the renin-angiotensin system in post-transplantation hypertension in patients w... 326209 - Effects of peep on cardiovascular dynamics after open-heart surgery: a new postoperativ... 19502719 - Effects of capsaicin and isoflavone on blood pressure and serum levels of insulin-like ... 15592569 - Does the reduction in systolic blood pressure alone explain the regression of left vent... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of veterinary medical science / the Japanese Society of Veterinary Science Volume: 54 ISSN: 0916-7250 ISO Abbreviation: J. Vet. Med. Sci. Publication Date: 1992 Dec |
Date Detail:
|
Created Date: 1993-02-09 Completed Date: 1993-02-09 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9105360 Medline TA: J Vet Med Sci Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 1191-3 Citation Subset: IM |
Affiliation:
|
Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiotensinogen
/
biosynthesis*,
physiology Animals Blood Pressure / genetics, physiology* Heart Rate / physiology Kinetics Male Mice Mice, Transgenic / physiology* Renin / physiology* Species Specificity |
| Chemical | |
Reg. No./Substance:
|
11002-13-4/Angiotensinogen; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Enhancing effect of butorphanol on medetomidine-induced sedation in pigs.
Next Document: Studies on closure of the ductus arteriosus in perinatal rats.