Document Detail

Species-specific kinetics of mouse renin contribute to maintenance of normal blood pressure in transgenic mice with overexpressed human angiotensinogen.
MedLine Citation:
PMID:  1477169     Owner:  NLM     Status:  MEDLINE    
Angiotensinogen, the precursor of a vasoactive octapeptide angiotensin II, is the only known natural substrate of renin, and its reaction exhibits strict species specificity and is the rate-limiting step in the renin-angiotensin system that controls the blood pressure. We measured blood pressure and heart rate of the transgenic mice with overproduced human angiotensinogen, and showed no significant difference in these parameters between transgenic and nontransgenic mice. We also provided evidence that mouse renin could not cleave human angiotensinogen, indicating a lack of angiotensin production from the human substrate. These results suggested that the blood pressure of transgenic mice is normally maintained, probably due to the inability of mouse renin to release angiotensin from the transgene products.
S Takahashi; A Fukamizu; T Hatae; Y Yamada; F Sugiyama; N Kajiwara; K Yagami; K Murakami
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  54     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-02-09     Completed Date:  1993-02-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1191-3     Citation Subset:  IM    
Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan.
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MeSH Terms
Angiotensinogen / biosynthesis*,  physiology
Blood Pressure / genetics,  physiology*
Heart Rate / physiology
Mice, Transgenic / physiology*
Renin / physiology*
Species Specificity
Reg. No./Substance:
11002-13-4/Angiotensinogen; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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