Document Detail

Species differences in the physiological activity of dietary lignan (sesamin and episesamin) in affecting hepatic fatty acid metabolism.
MedLine Citation:
PMID:  15005823     Owner:  NLM     Status:  MEDLINE    
The effect of sesame (Sesamum orientale) lignan preparation containing equivalent amounts of sesamin and episesamin on hepatic fatty acid metabolism was compared in rats, mice and hamsters. Animals were fed on either a diet free of lignan or a diet containing 2 g lignan/kg for 15 d. The lignan preparation greatly increased hepatic activity and the mRNA levels of enzymes involved in fatty acid oxidation, while it strongly down-regulated those of enzymes involved in lipogenesis in rats. In contrast, lignan did not modify these variables in mice and hamsters. Changes observed, if any, were more attenuated in these mice and hamsters than in rats. Sesamin and episesamin concentrations in serum and liver of animals fed on lignan-containing diets were significantly greater (P<0.05) in rats than in mice and hamsters. Moreover, sesamin:episesamin values in tissues were far from that expected from the value in the lignan preparation given to the animals and were dependent on the animal species. Liver microsomes from each animal species degraded sesamin and episesamin in the presence of NADPH. The combined value of sesamin and episesamin degradation rates was lower in rats than in mice and hamsters. In addition, there was considerable diversity in the specificity of the enzyme reaction toward sesamin and episesamin among animal species. The differences in the amounts of lignan remaining in the tissues may account for the species dependence of the physiological activity of sesame lignan in affecting hepatic fatty acid oxidation and synthesis.
Masayo Kushiro; Yoko Takahashi; Takashi Ide
Related Documents :
3934303 - Decreased hepatic production of very low density lipoproteins following activation of f...
8687483 - Glucuronide conjugates of 4-aminobiphenyl and its n-hydroxy metabolites. ph stability a...
9220253 - Solitary corneal myxoma.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of nutrition     Volume:  91     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-09     Completed Date:  2004-03-30     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  377-86     Citation Subset:  IM    
Laboratory of Nutritional Biochemistry, National Food Research Institute, 2-1-12 Kannondai, Tsukuba 305-8642, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antioxidants / pharmacology
Blotting, Northern
Dioxoles / metabolism,  pharmacology*
Fatty Acids / biosynthesis,  metabolism*
Insulin / blood
Lignans / metabolism,  pharmacology*
Lipids / blood
Liver / drug effects*,  enzymology,  metabolism
Mice, Inbred ICR
Microsomes, Liver / metabolism
RNA, Messenger / genetics
Rats, Sprague-Dawley
Species Specificity
Reg. No./Substance:
0/Antioxidants; 0/Dioxoles; 0/Fatty Acids; 0/Lignans; 0/Lipids; 0/RNA, Messenger; 11061-68-0/Insulin; 607-80-7/sesamin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Lowering dietary phosphorus concentrations reduces kidney calcification, but does not adversely affe...
Next Document:  Reproductive potential of male Portan rats exposed to various levels of lead with regard to zinc sta...