Document Detail


Species differences in the metabolism of suprofen in laboratory animals and man.
MedLine Citation:
PMID:  2859175     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The metabolism of the oral anti-inflammatory agent suprofen (S), 2-4-(2-thienylcarbonyl)phenyl)propionic acid, has been studied in mice, rats, guinea pigs, dogs, monkeys, and human volunteers. The major metabolites of S in the serum, urine, and feces of these species were determined by GC/MS and HPLC techniques. The metabolic pathways of S in these species involved reduction of the ketone group to an alcohol (S-OH), hydroxylation of the thiophene ring (T-OH), elimination of the thiophene ring to a dicarboxylic acid (S-COOH), and conjugation with glucuronic acid or taurine. In 72-hr urine and feces of these species after po dosing of 1.6 to 2 mg/kg of S, S and these metabolites accounted for 46 to 92% of the dose and were mainly excreted in the urine. S was present as a major product (excreted mainly in conjugated form) in all species. S-OH was a major component in guinea pig and dog but a minor one in other species. T-OH was identified as a major metabolite in monkey, rat, mouse, and man, but a minor one in guinea pig, and it was absent in the dog. S-COOH was present as the minor metabolite in mouse and rat, and present at trace levels in dog, monkey, and man. Conjugation of the propionic acid functionality with taurine was observed only in the dog; in the other species, conjugation with glucuronic acid was extensive. Absorption parameters of S in the rat and monkey were similar to those in man; however, other species were very different from man.
Authors:
Y Mori; N Kuroda; Y Sakai; F Yokoya; K Toyoshi; S Baba
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Drug metabolism and disposition: the biological fate of chemicals     Volume:  13     ISSN:  0090-9556     ISO Abbreviation:  Drug Metab. Dispos.     Publication Date:    1985 Mar-Apr
Date Detail:
Created Date:  1985-06-19     Completed Date:  1985-06-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421550     Medline TA:  Drug Metab Dispos     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  239-45     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromatography, High Pressure Liquid
Dogs
Feces / analysis
Female
Gas Chromatography-Mass Spectrometry
Guinea Pigs
Humans
Kinetics
Macaca fascicularis
Male
Mice
Phenylpropionates / metabolism*
Rats
Rats, Inbred Strains
Species Specificity
Suprofen / blood,  metabolism*,  urine
Chemical
Reg. No./Substance:
0/Phenylpropionates; 40828-46-4/Suprofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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