Document Detail

Species differences in mammalian renal function: 5-HIAA, a reported marker of tubular secretion in humans, is handled exclusively by filtration in the rat.
MedLine Citation:
PMID:  7521767     Owner:  NLM     Status:  MEDLINE    
Renal clearance of endogenous 5-HIAA has been shown to be similar to that of PAH in humans. The present study compared 5-HIAA and PAH clearances in rats. It showed that the clearance of 5-HIAA in rats was identical to that of inulin and creatinine. This suggests that in this species, 5-HIAA is only filtered and not secreted by the tubules in contrast to what is observed in humans.
M Burtin; J L Elghozi; D Laude; C Kleinknecht
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Experimental nephrology     Volume:  1     ISSN:  1018-7782     ISO Abbreviation:  Exp. Nephrol.     Publication Date:    1993 Jan-Feb
Date Detail:
Created Date:  1994-10-10     Completed Date:  1994-10-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9302239     Medline TA:  Exp Nephrol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  62-4     Citation Subset:  IM    
INSERM U192, Hôpital des Enfants-Malades, Paris, France.
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MeSH Terms
Biological Markers
Hydroxyindoleacetic Acid / blood,  pharmacokinetics*
Kidney / metabolism*
Kidney Tubules / metabolism,  secretion
Metabolic Clearance Rate
Rats, Sprague-Dawley
Renal Circulation / physiology
Species Specificity
p-Aminohippuric Acid / blood,  pharmacokinetics
Reg. No./Substance:
0/Biological Markers; 54-16-0/Hydroxyindoleacetic Acid; 61-78-9/p-Aminohippuric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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