Document Detail

Species differences in decompression.
MedLine Citation:
PMID:  462649     Owner:  NLM     Status:  MEDLINE    
In an effort to bring together the diverse laboratory-animal decompression studies, a literature review and statistical evaluation were undertaken. Although 22 different species that had been used in decompression studies were identified, systematic data were available for only 7 of these species: man, goat, dog, guinea-pig, rat, hamster, and mouse. Mathematical functions using physiological data on these seven species were developed to estimate 1) saturation time (the time for the body to equilibrate after an increase in hydrostatic pressure), and 2) no-decompression saturation-exposure limits (the maximum saturation-exposure pressure from which an abrupt return to 1 ATA can be tolerated). Data from man, rat, and mouse were used to develop physiological relationships for two additional decompression variables: change in pressure-reduction limits associated with increased exposure pressure and time to onset of decompression symptoms. Finally, data on rats for two other decompression variables, gas elimination time and optimum decompression stop time, are discussed in the hope that this will stimulate additional animal laboratory research in other mammalians. The general functional relationships developed in this paper provide a preliminary and rough means for extrapolating among species the decompression results obtained during animal laboratory experiments.
T E Berghage; T D David; C V Dyson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Undersea biomedical research     Volume:  6     ISSN:  0093-5387     ISO Abbreviation:  Undersea Biomed Res     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-09-25     Completed Date:  1979-09-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421514     Medline TA:  Undersea Biomed Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-13     Citation Subset:  IM; S    
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MeSH Terms
Decompression Sickness / physiopathology*
Guinea Pigs
Heart Rate
Hydrostatic Pressure
Species Specificity
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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