Document Detail


Species-dependent premature degradation of absorbable suture materials caused by infection--impact on the choice of thread in vascular surgery.
MedLine Citation:
PMID:  15461069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In case of infection after vascular reconstruction, preference is often given to absorbable suture material with the aim of preventing persistence of infection. We have investigated the functional deficit of absorbable sutures on incubation with various different bacteria.
MATERIAL AND METHODS: Four suture materials Dexon bicolor, Vicryl, Maxon and PDS II--were placed in contact with reference bacterial cultures (Staphylococcus aureus, Pseudomonas aeroginosa, E. coli, coagulase-negative staphylococci and Proteus mirabilis). The bacteria were incubated for 7 days at 37 degrees C, together with the suture material. A logarithmic phase (Group A) and a static phase (Group B) were simulated. The linear tensile strength (LTS) of the suture material was measured (Instron Tensiometer).
RESULTS: In the case of Staphylococcus aureus, a significant decrease in LTS was established for Dexon bicolor (group A: 31%, group B: 22%), and Vicryl (53% and 43%), but not for the monofilament threads. With regard to the other bacteria, a considerably more dramatic effect was observed: in both groups the braided sutures had completely disintegrated after 7 days. The monofilament sutures also revealed a significant loss of function (Maxon: 88%, PDS II 66%).
CONCLUSIONS: The absorbable sutures revealed a premature, species-dependent loss of function due to the presence of the bacteria. On the basis of our results, the use of absorbable threads for vessel sutures in case of infection cannot be recommended, with the exception of monofilament material in a monocultural Staphylococcus aureus infection.
Authors:
A Larena-Avellaneda; E S Debus; H Diener; U A Dietz; S Franke; A Thiedel
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  VASA. Zeitschrift für Gefässkrankheiten     Volume:  33     ISSN:  0301-1526     ISO Abbreviation:  VASA     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-10-05     Completed Date:  2004-11-30     Revised Date:  2012-10-19    
Medline Journal Info:
Nlm Unique ID:  0317051     Medline TA:  Vasa     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  165-9     Citation Subset:  IM    
Affiliation:
Chirurgische Klinik und Poliklinik, Universitätsklinik Würzburg, Germany. Larena_a@chirurgie.uni-wuerzburg.de
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MeSH Terms
Descriptor/Qualifier:
Absorbable Implants / microbiology*
Animals
Bacteria / classification*,  growth & development*
Bacterial Infections / physiopathology
Biocompatible Materials / chemistry*
Equipment Failure
Equipment Failure Analysis
Humans
Materials Testing
Species Specificity
Sutures / microbiology*
Tensile Strength
Chemical
Reg. No./Substance:
0/Biocompatible Materials

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