Document Detail


Speciation of insulin-mimetic VO(IV)-containing drugs in blood serum.
MedLine Citation:
PMID:  10885465     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The biospeciations of three potential insulin-mimetic VO(IV) compounds, VO(maltolate)2, VO(picolinate)2 and VO(6-Me-picolinate)2, in blood serum were assessed via modelling calculations, using the stability constants reported in the literature for the binary insulin-mimetic complexes and their ternary complexes formed with the most important low molecular mass binders in the serum: oxalic acid, lactic acid, citric acid and phosphate. The binding capabilities of two high molecular mass serum proteins, albumin and transferrin, were also taken into account.
Authors:
T Kiss; E Kiss; E Garribba; H Sakurai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of inorganic biochemistry     Volume:  80     ISSN:  0162-0134     ISO Abbreviation:  J. Inorg. Biochem.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-10-04     Completed Date:  2001-02-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905788     Medline TA:  J Inorg Biochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  65-73     Citation Subset:  IM    
Affiliation:
Department of Inorganic and Analytical Chemistry, József Attila University, Szeged, Hungary. tkiss@chem.u-szeged.hu
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MeSH Terms
Descriptor/Qualifier:
Citric Acid / chemistry
Electron Spin Resonance Spectroscopy
Hydrogen-Ion Concentration
Insulin / pharmacology
Lactic Acid / chemistry
Ligands
Models, Molecular
Molecular Structure
Phosphates / chemistry
Picolinic Acids / chemistry
Serum Albumin / metabolism
Transferrin / metabolism
Vanadates / blood*
Chemical
Reg. No./Substance:
0/Ligands; 0/Phosphates; 0/Picolinic Acids; 0/Serum Albumin; 0/Vanadates; 11061-68-0/Insulin; 11096-37-0/Transferrin; 50-21-5/Lactic Acid; 77-92-9/Citric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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