Document Detail

Special features of total knee replacement in hemophilia.
MedLine Citation:
PMID:  24219549     Owner:  NLM     Status:  In-Data-Review    
Total knee replacement is an operation frequently needed by hemophilia patients, which greatly improves their quality of life. This operation, however, carries a higher risk of bleeding and infection for hemophiliacs than it does for osteoarthritis sufferers. It is advisable to implant prosthetic components using antibiotic-loaded cement. It is essential to maintain a level of 100% of the replacement clotting factor for 2 weeks. Hematological treatment must be established, depending on the patient's factor levels and other pharmacokinetic parameters such as recovery and half-life, optimal doses and treatment time. It is preferable to use general anesthesia due to the risk of spinal bleeding. The lifespan of total knee replacement in hemophilic patients is shorter than in patients with osteoarthritis because of the increased risk of infection.
Emerito Carlos Rodriguez-Merchan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of hematology     Volume:  6     ISSN:  1747-4094     ISO Abbreviation:  Expert Rev Hematol     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485942     Medline TA:  Expert Rev Hematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  637-42     Citation Subset:  IM    
Department of Orthopaedic Surgery, La Paz University Hospital, Paseo de la Castellana 261, 28046-Madrid, Spain and Autonomous University, School of Medicine, Madrid, Spain
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