Document Detail

Special delivery: targeted therapy with small RNAs.
MedLine Citation:
PMID:  21490679     Owner:  NLM     Status:  Publisher    
Harnessing RNA interference using small RNA-based drugs has great potential to develop drugs designed to knock down expression of any disease-causing gene, thereby greatly expanding the universe of possible drug targets. However, delivering small RNAs into specific tissues and cells is still a hurdle. Here, we review recent progress in overcoming systemic, local and cellular barriers to RNA drug delivery, focusing on strategies for targeted uptake.Gene Therapy advance online publication, 14 April 2011; doi:10.1038/gt.2011.56.
D Peer; J Lieberman
Related Documents :
21443229 - Naphthalene triplet excited state as a probe for the assessment of drug distribution in...
19621069 - Can the relationship between doctors and drug companies ever be a healthy one?
21180649 - Trioxaquines: hybrid molecules for the treatment of malaria.
21429599 - Previously unsuspected widespread cellular and tissue distribution of β-adrenoceptors ...
21246559 - Pegylated phosphotidylethanolamine inhibiting p-glycoprotein expression and enhancing r...
22966909 - Co-proccessed excipients with enhanced direct compression functionality for improved ta...
23063179 - Urb-754: a new class of designer drug and 12 synthetic cannabinoids detected in illegal...
10531629 - Use of monetary reinforcers by cocaine-dependent outpatients.
6108009 - Kurloff cell levels in the peripheral blood of normal guinea-pigs treated with cytotoxi...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-14
Journal Detail:
Title:  Gene therapy     Volume:  -     ISSN:  1476-5462     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421525     Medline TA:  Gene Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Laboratory of Nanomedicine, Department of Cell Research and Immunology, GS Wise Faculty of Life Science and Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, Israel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  SMG1 and NIK regulate apoptosis induced by Smac mimetic compounds.
Next Document:  CDK4 and cyclin D1 allow human myogenic cells to recapture growth property without compromising diff...