Document Detail


Special circumstances: trophic feeds, necrotizing enterocolitis and bronchopulmonary dysplasia.
MedLine Citation:
PMID:  17189719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are many unresolved issues regarding how to feed the extremely-low-birth-weight (ELBW) infant. Trophic feedings of small volumes of breast milk or formula do not appear to increase the incidence of necrotizing enterocolitis (NEC). For prevention of NEC, breast milk, antenatal steroids and fluid restriction each confers a benefit. Because the incidence of NEC is relatively low, to determine if a particular prevention strategy is effective, large numbers of infants would need to be enrolled in a prospective, randomized controlled trial, and such trials are rare. Candidate therapies for NEC prevention that warrant further study include oral immunoglobulins, probiotics, long-chain polyunsaturated fatty acids and arginine. Suboptimal nutrition in ELBW infants is common in the early postnatal period. This is also the most critical time for the development of bronchopulmonary dysplasia, when even brief periods of malnutrition have significant effects on lung development and growth.
Authors:
Regina M Reynolds; Patti J Thureen
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-12-26
Journal Detail:
Title:  Seminars in fetal & neonatal medicine     Volume:  12     ISSN:  1744-165X     ISO Abbreviation:  -     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-22     Completed Date:  2007-04-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101240003     Medline TA:  Semin Fetal Neonatal Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  64-70     Citation Subset:  IM    
Affiliation:
University of Colorado Health Sciences Center, The Children's Hospital, 4200 E. 9th Avenue, B-195, Denver, CO 80262, USA. regina.reynolds@uchsc.edu
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MeSH Terms
Descriptor/Qualifier:
Bronchopulmonary Dysplasia / prevention & control*
Enteral Nutrition
Enterocolitis, Necrotizing / prevention & control*
Humans
Infant Food*
Infant Nutritional Physiological Phenomena
Infant, Newborn
Infant, Very Low Birth Weight*
Milk, Human*
Nutritional Requirements
Parenteral Nutrition
Randomized Controlled Trials as Topic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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