Document Detail

A special, strict, fat-reduced, and carbohydrate-modified diet leads to marked weight reduction even in overweight adolescents with Prader-Willi syndrome (PWS).
MedLine Citation:
PMID:  19768349     Owner:  NLM     Status:  MEDLINE    
Hyperphagia is a frequent symptom in patients with Prader-Willi Syndrome (PWS) and results in marked obesity with the risk of metabolic and cardiovascular complications. Previously, we reported that our special diet for PWS patients is effective in the long run, if started early at about 2 years of age. Our objective in this study was to investigate if our special diet is also effective in PWS adolescents who are already overweight. We provided a strict, fat-reduced, and carbohydrate-modified diet, consisting of 10 kcal/cm height, to five adolescents (two female, three male) with PWS. Patients were prospectively followed at our center for 2-6 years. BMI, BMI-SDS, and Weight-for-Height Index were recorded over that period. The special diet was started at a mean age of 16 years (range: 14.1-18.9 years) and initial BMI was 41.3 kg/m(2) (range: 32.4-55.5 kg/m(2)), corresponding to BMI-SDS +3.6 (range: +2.8 to +4.5 SDS). Weight-for-Height Index was 243% (range: 190-339%). After 2 years of the diet, BMI decreased to 33 kg/m(2) (range: 26.7-38 kg/m(2)), as well as BMI-SDS +2.7 (range: 1.7-3.4 SDS) and Weight-for-Height Index to 191% (range: 157-232%); p < 0.01. The special diet was still effective in reducing weight after 4-6 years, with a mean BMI of 30.5 kg/m(2) (range: 24.6-34.5 kg/m(2)) and a mean BMI-SDS of +2.1 (range: 0.7-2.9). We conclude that in a period of 2-6 years, our strict, fat-reduced, and carbohydrate-modified diet, with 10 kcal/cm height, is effective even in adolescents with PWS who are already overweight.
Walter Bonfig; Kathi Dokoupil; Heinrich Schmidt
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Publication Detail:
Type:  Journal Article     Date:  2009-09-14
Journal Detail:
Title:  TheScientificWorldJournal     Volume:  9     ISSN:  1537-744X     ISO Abbreviation:  ScientificWorldJournal     Publication Date:  2009  
Date Detail:
Created Date:  2009-09-21     Completed Date:  2009-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101131163     Medline TA:  ScientificWorldJournal     Country:  England    
Other Details:
Languages:  eng     Pagination:  934-9     Citation Subset:  IM    
Dr. von Hauner Children's Hospital, University of Munich, Germany.
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MeSH Terms
Body Mass Index
Dietary Carbohydrates / administration & dosage*
Dietary Fats / administration & dosage*
Overweight / diet therapy*
Prader-Willi Syndrome / diet therapy*
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats

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