| Spatiotemporal pattern of commitment to slowed proliferation in the embryonic mouse heart indicates progressive differentiation of the cardiac conduction system. | |
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MedLine Citation:
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PMID: 12923887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patterns of DNA synthesis in the developing mouse heart between ED7.5-18.5 were studied by a combination of thymidine and bromodeoxyuridine labeling techniques. From earliest stages, we found zones of slow myocyte proliferation at both the venous and arterial poles of the heart, as well as in the atrioventricular region. The labeling index was distinctly higher in nonmyocardial populations (endocardium, epicardium, and cardiac cushions). Ventricular trabeculae showed lower proliferative activity than the ventricular compact layer after their appearance at ED9.5. Low labeling was observed in the pectinate muscles of the atria from ED11.5. The His bundle, bundle branches, and Purkinje fiber network likewise were distinguished by their lack of labeling. Thymidine birthdating (label dilution) showed that the cells in these emerging components of the cardiac conduction system terminally differentiated between ED8.5-13.5. These patterns of slowed proliferation correlate well with those in other species, and can serve as a useful marker for the forming conduction system. |
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Authors:
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David Sedmera; Maria Reckova; Angela DeAlmeida; Steven R Coppen; Steven W Kubalak; Robert G Gourdie; Robert P Thompson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Volume: 274 ISSN: 1552-4884 ISO Abbreviation: - Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-08-18 Completed Date: 2004-05-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101234285 Medline TA: Anat Rec A Discov Mol Cell Evol Biol Country: United States |
Other Details:
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Languages: eng Pagination: 773-7 Citation Subset: IM |
Copyright Information:
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Copyright 2003 Wiley-Liss, Inc. |
Affiliation:
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Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA. sedmerad@musc.edu. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / analysis Cell Aging Cell Differentiation Cell Division Embryo, Mammalian / cytology*, physiology Heart / embryology* Heart Conduction System / cytology, embryology* Mice Myocytes, Cardiac / cytology, metabolism Time Factors Tissue Distribution |
| Grant Support | |
ID/Acronym/Agency:
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HD39946/HD/NICHD NIH HHS; HL50582/HL/NHLBI NIH HHS; HL63714/HL/NHLBI NIH HHS; RR16434/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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