Document Detail

Spatiotemporal pattern of commitment to slowed proliferation in the embryonic mouse heart indicates progressive differentiation of the cardiac conduction system.
MedLine Citation:
PMID:  12923887     Owner:  NLM     Status:  MEDLINE    
Patterns of DNA synthesis in the developing mouse heart between ED7.5-18.5 were studied by a combination of thymidine and bromodeoxyuridine labeling techniques. From earliest stages, we found zones of slow myocyte proliferation at both the venous and arterial poles of the heart, as well as in the atrioventricular region. The labeling index was distinctly higher in nonmyocardial populations (endocardium, epicardium, and cardiac cushions). Ventricular trabeculae showed lower proliferative activity than the ventricular compact layer after their appearance at ED9.5. Low labeling was observed in the pectinate muscles of the atria from ED11.5. The His bundle, bundle branches, and Purkinje fiber network likewise were distinguished by their lack of labeling. Thymidine birthdating (label dilution) showed that the cells in these emerging components of the cardiac conduction system terminally differentiated between ED8.5-13.5. These patterns of slowed proliferation correlate well with those in other species, and can serve as a useful marker for the forming conduction system.
David Sedmera; Maria Reckova; Angela DeAlmeida; Steven R Coppen; Steven W Kubalak; Robert G Gourdie; Robert P Thompson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology     Volume:  274     ISSN:  1552-4884     ISO Abbreviation:  Anat Rec A Discov Mol Cell Evol Biol     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-18     Completed Date:  2004-05-21     Revised Date:  2014-02-10    
Medline Journal Info:
Nlm Unique ID:  101234285     Medline TA:  Anat Rec A Discov Mol Cell Evol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  773-7     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
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MeSH Terms
Biological Markers / analysis
Cell Aging
Cell Differentiation
Cell Division
Embryo, Mammalian / cytology*,  physiology
Heart / embryology*
Heart Conduction System / cytology,  embryology*
Myocytes, Cardiac / cytology,  metabolism
Time Factors
Tissue Distribution
Grant Support
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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