Document Detail

Spatiotemporal organization and mechanosensory function of podosomes.
MedLine Citation:
PMID:  24658050     Owner:  NLM     Status:  Publisher    
Podosomes are small, circular adhesions formed by cells such as osteoclasts, macrophages, dendritic cells, and endothelial cells. They comprise a protrusive actin core module and an adhesive ring module composed of integrins and cytoskeletal adaptor proteins such as vinculin and talin. Furthermore, podosomes are associated with an actin network and often organize into large clusters. Recent results from our laboratory and others have shed new light on podosome structure and dynamics, suggesting a revision of the classical "core-ring" model. Also, these studies demonstrate that the adhesive and protrusive module are functionally linked by the actin network likely facilitating mechanotransduction as well as providing feedback between these two modules. In this commentary, we briefly summarize these recent advances with respect to the knowledge on podosome structure and discuss force distribution mechanisms within podosomes and their emerging role in mechanotransduction.
Koen van den Dries; Matteo Bolomini-Vittori; Alessandra Cambi
Publication Detail:
Type:  REVIEW     Date:  2014-2-20
Journal Detail:
Title:  Cell adhesion & migration     Volume:  8     ISSN:  1933-6926     ISO Abbreviation:  Cell Adh Migr     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-3-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101469464     Medline TA:  Cell Adh Migr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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