| Spatiotemporal interactions in retinal prosthesis subjects. | |
| | |
MedLine Citation:
|
PMID: 19741248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: Vision loss due to retinitis pigmentosa affects an estimated 15 million people worldwide. Through collaboration between Second Sight Medical Products, Inc., and the Doheny Eye Institute, six blind human subjects underwent implantation with epiretinal 4 x 4 electrode arrays designed to directly stimulate the remaining cells of the retina, with the goal of restoring functional vision by applying spatiotemporal patterns of stimulation. To better understand spatiotemporal interactions between electrodes during synchronous and asynchronous stimulation, the authors investigated how percepts changed as a function of pulse timing across the electrodes. METHODS: Pulse trains (20, 40, 80, and 160 Hz) were presented on groups of electrodes with 800, 1600, or 2400 microm center-to-center separation. Stimulation was either synchronous (pulses were presented simultaneously across electrodes) or asynchronous (pulses were phase shifted). Using a same-different discrimination task, the authors were able to evaluate how the perceptual quality of the stimuli changed as a function of phase shifts across multiple electrodes. RESULTS: Even after controlling for electric field interactions, subjects could discriminate between spatiotemporal pulse train patterns based on differences of phase across electrodes as small as 3 ms. These findings suggest that the quality of the percept is affected not only by electric field interactions but also by spatiotemporal interactions at the neural level. CONCLUSIONS: During multielectrode stimulation, interactions between electrodes have a significant influence on the quality of the percept. Understanding how these spatiotemporal interactions at the neural level influence percepts during multielectrode stimulation is fundamental to the successful design of a retinal prosthesis. |
| | |
Authors:
|
Alan Horsager; Robert J Greenberg; Ione Fine |
Related Documents
:
|
11699528 - Entrainment by an extracellular ac stimulus in a computational model of cardiac tissue. 11396398 - The pattern electroretinogram (perg) with contralateral corneal reference. 20657038 - Influence of electrical contacts on the 1/f noise in individual multi-walled carbon nan... 7055698 - Differential effects of exposure to an imprinting stimulus on 'spontaneous' neuronal ac... 14763228 - Response of human skull to bone-conducted sound in the audiometric-ultrasonic range. 3884728 - Initiation of luminol-based luminescence by injection of a single reagent, coupled with... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-09-09 |
Journal Detail:
|
Title: Investigative ophthalmology & visual science Volume: 51 ISSN: 1552-5783 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-01-19 Completed Date: 2010-02-17 Revised Date: 2010-09-27 |
Medline Journal Info:
|
Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 1223-33 Citation Subset: IM |
Affiliation:
|
Neuroscience Graduate Program, University of Southern California, Los Angeles, California 90033, USA. horsager@usc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blindness
/
rehabilitation Electric Stimulation Therapy Electrodes, Implanted* Humans Male Microelectrodes* Middle Aged Prostheses and Implants* Retina / physiopathology*, surgery Retinitis Pigmentosa / physiopathology*, surgery Sensory Thresholds / physiology* Visual Perception / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
EY012893/EY/NEI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A Novel Rhodopsin Mutation Causes Severe Retinal Degeneration.
Next Document: Hemoglobin expression and regulation in glaucoma: insights into retinal ganglion cell oxygenation.