Document Detail

Spatiotemporal dynamics of clotting and pattern formation in human blood.
MedLine Citation:
PMID:  9838209     Owner:  NLM     Status:  MEDLINE    
We examined the spatial dynamics of in vitro clot growth in human blood and plasma and found that initially, a clot grows at a constant speed, then abruptly stops and becomes surrounded by an 'inhibition zone' in which coagulation is strongly suppressed. We also observed the formation of 'stratified structures' (target patterns) in which solid layers alternated with liquid plasma. These and other spatial regimes of clotting are explained in terms of two interacting concentration waves propagating without attenuation. The experimental results are consistent with a hypothesis that blood is a bi-excitable medium, a new type of excitable medium.
F I Ataullakhanov; G T Guria; V I Sarbash; R I Volkova
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1425     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-01-28     Completed Date:  1999-01-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  453-68     Citation Subset:  IM    
National Research Center for Hematology, Russian Academy of Medical Sciences, Novozykovskii 4a, Moscow 125167, Russia.
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MeSH Terms
Blood Coagulation / physiology*
Blood Platelets / physiology
Fibrin / biosynthesis,  chemistry
Plasma / physiology
Scattering, Radiation
Thrombin / biosynthesis
Time Factors
Reg. No./Substance:
9001-31-4/Fibrin; EC

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