| Spatiotemporal dynamics of bimanual integration in human somatosensory cortex and their relevance to bimanual object manipulation. | |
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MedLine Citation:
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PMID: 22514328 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Little is known about the spatiotemporal dynamics of cortical responses that integrate slightly asynchronous somatosensory inputs from both hands. This study aimed to clarify the timing and magnitude of interhemispheric interactions during early integration of bimanual somatosensory information in different somatosensory regions and their relevance for bimanual object manipulation and exploration. Using multi-fiber probabilistic diffusion tractography and MEG source analysis of conditioning-test (C-T) median nerve somatosensory evoked fields in healthy human subjects, we sought to extract measures of structural and effective callosal connectivity between different somatosensory cortical regions and correlated them with bimanual tactile task performance. Neuromagnetic responses were found in major somatosensory regions, i.e., primary somatosensory cortex SI, secondary somatosensory cortex SII, posterior parietal cortex, and premotor cortex. Contralateral to the test stimulus, SII activity was maximally suppressed by 51% at C-T intervals of 40 and 60 ms. This interhemispheric inhibition of the contralateral SII source activity correlated directly and topographically specifically with the fractional anisotropy of callosal fibers interconnecting SII. Thus, the putative pathway that mediated inhibitory interhemispheric interactions in SII was a transcallosal route from ipsilateral to contralateral SII. Moreover, interhemispheric inhibition of SII source activity correlated directly with bimanual tactile task performance. These findings were exclusive to SII. Our data suggest that early interhemispheric somatosensory integration primarily occurs in SII, is mediated by callosal fibers that interconnect homologous SII areas, and has behavioral importance for bimanual object manipulation and exploration. |
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Authors:
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Patrick Jung; Johannes C Klein; Michael Wibral; Karsten Hoechstetter; Barbara Bliem; Ming-Kuei Lu; Mathias Wahl; Ulf Ziemann |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 32 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 5667-77 Citation Subset: IM |
Affiliation:
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Department of Neurology and Magnetoencephalography Unit, Brain Imaging Center, Goethe University Frankfurt, D-60528 Frankfurt, Germany, Department of Psychiatry and Psychotherapy, University Medical Center of the Gutenberg University Mainz, D-55131 Mainz, Germany, and Department of Neurology, China Medical University Hospital, Taichung, Taiwan 40402, China. |
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