Document Detail


Spatiotemporal temperature distribution and cancer cell death in response to extracellular hyperthermia induced by gold nanorods.
MedLine Citation:
PMID:  20387828     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasmonic nanoparticles have shown promise in hyperthermic cancer therapy, both in vitro and in vivo. Previous reports have described hyperthermic ablation using targeted and nontargeted nanoparticles internalized by cancer cells, but most reports do not describe a theoretical analysis for determining optimal parameters. The focus of the current research was first to evaluate the spatiotemporal temperature distribution and cell death induced by extracellular hyperthermia in which gold nanorods (GNRs) were maintained in the dispersion outside human prostate cancer cells. The nanorod dispersion was irradiated with near-infrared (NIR) laser, and the spatiotemporal distribution of temperature was determined experimentally. This information was employed to develop and validate theoretical models of spatiotemporal temperature profiles for gold nanorod dispersions undergoing laser irradiation and the impact of the resulting heat generation on the viability of human prostate cancer cells. A cell injury/death model was then coupled to the heat transfer model to predict spatial and temporal variations in cell death and injury. The model predictions agreed well with experimental measurements of both temperature and cell death profiles. Finally, the model was extended to examine the impact of selective binding of gold nanorods to cancer cells compared to nonmalignant cells, coupled with a small change in cell injury activation energy. The impact of these relatively minor changes results in a dramatic change in the overall cell death rate. Taken together, extracellular hyperthermia using gold nanorods is a promising strategy, and tailoring the cellular binding efficacy of nanorods can result in varying therapeutic efficacies using this approach.
Authors:
Huang-Chiao Huang; Kaushal Rege; Jeffrey J Heys
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  ACS nano     Volume:  4     ISSN:  1936-086X     ISO Abbreviation:  ACS Nano     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-25     Completed Date:  2010-09-07     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101313589     Medline TA:  ACS Nano     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2892-900     Citation Subset:  IM    
Affiliation:
Chemical Engineering, Arizona State University, Tempe, Arizona 85287-6106, USA.
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MeSH Terms
Descriptor/Qualifier:
Cell Death / drug effects,  radiation effects
Cell Line, Tumor
Cell Survival / drug effects,  radiation effects
Extracellular Space / drug effects*,  metabolism
Gold / chemistry,  pharmacology*
Humans
Hyperthermia, Induced*
Lasers
Male
Models, Biological
Nanotubes / chemistry*
Prostatic Neoplasms / pathology*,  therapy*
Temperature*
Time Factors
Grant Support
ID/Acronym/Agency:
5R21CA133618-02/CA/NCI NIH HHS; R21 CA133618-02/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
7440-57-5/Gold
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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