| Spatiotemporal BOLD dynamics from a poroelastic hemodynamic model. | |
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MedLine Citation:
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PMID: 20665966 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A quantitative theory is developed for the relationship between stimulus and the resulting blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) signal, including both spatial and temporal dynamics for the first time. The brain tissue is modeled as a porous elastic medium, whose interconnected pores represent the vasculature. The model explicitly incorporates conservation of blood mass, interconversion of oxygenated and deoxygenated hemoglobin, force balance within the blood and of blood pressure with vessel walls, and blood flow modulation due to neuronal activity. In appropriate limits it is shown to reproduce prior Balloon models of hemodynamic response, which do not include spatial variations. The regime of validity of such models is thereby clarified by elucidating their assumptions, and when these break down, for example when voxel sizes become small. |
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Authors:
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P M Drysdale; J P Huber; P A Robinson; K M Aquino |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of theoretical biology Volume: 265 ISSN: 1095-8541 ISO Abbreviation: J. Theor. Biol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-27 Completed Date: 2010-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376342 Medline TA: J Theor Biol Country: England |
Other Details:
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Languages: eng Pagination: 524-34 Citation Subset: IM |
Affiliation:
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School of Physics, University of Sydney, NSW 2006, Australia. p.drysdale@physics.usyd.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / physiology Cerebrovascular Circulation / physiology Elasticity / physiology* Hemodynamics / physiology* Hemoglobins / metabolism Models, Biological* Neurons / physiology Oxygen / blood* Porosity Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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