Document Detail


Spatio-temporal information analysis of event-related BOLD responses.
MedLine Citation:
PMID:  17188515     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new approach for analysis of event-related fMRI (BOLD) signals is proposed. The technique is based on measures from information theory and is used both for spatial localization of task-related activity, as well as for extracting temporal information regarding the task-dependent propagation of activation across different brain regions. This approach enables whole brain visualization of voxels (areas) most involved in coding of a specific task condition, the time at which they are most informative about the condition, as well as their average amplitude at that preferred time. The approach does not require prior assumptions about the shape of the hemodynamic response function (HRF) nor about linear relations between BOLD response and presented stimuli (or task conditions). We show that relative delays between different brain regions can also be computed without prior knowledge of the experimental design, suggesting a general method that could be applied for analysis of differential time delays that occur during natural, uncontrolled conditions. Here we analyze BOLD signals recorded during performance of a motor learning task. We show that, during motor learning, the BOLD response of unimodal motor cortical areas precedes the response in higher-order multimodal association areas, including posterior parietal cortex. Brain areas found to be associated with reduced activity during motor learning, predominantly in prefrontal brain regions, are informative about the task typically at significantly later times.
Authors:
Galit Fuhrmann Alpert; Fellice T Sun; Daniel Handwerker; Mark D'Esposito; Robert T Knight
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-12-22
Journal Detail:
Title:  NeuroImage     Volume:  34     ISSN:  1053-8119     ISO Abbreviation:  Neuroimage     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-06     Completed Date:  2007-05-14     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1545-61     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Brain / anatomy & histology*,  physiology*
Brain Mapping / methods*
Cues
Evoked Potentials / physiology*
Fingers / innervation
Humans
Image Processing, Computer-Assisted / methods
Magnetic Resonance Imaging / methods
Models, Neurological
Psychomotor Performance
Reaction Time
Grant Support
ID/Acronym/Agency:
MH63901/MH/NIMH NIH HHS; NS21135/NS/NINDS NIH HHS; P0 NS40813/NS/NINDS NIH HHS; R01 NS021135/NS/NINDS NIH HHS; R01 NS021135-20/NS/NINDS NIH HHS
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