Document Detail


Spatio-temporal characteristics of low-frequency BOLD signal fluctuations in isoflurane-anesthetized rat brain.
MedLine Citation:
PMID:  18339559     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the spatio-temporal characteristics of the resting state low-frequency fluctuations in fMRI-BOLD signal in isoflurane-anesthetized rats. fMRI-BOLD measurements at 9.4 T were made during normal and exsanguinated condition previously known to alter cerebral blood flow (CBF) fluctuations in anesthetized rats. fMRI signal time series were low pass filtered and studied by spectral analysis. During normal conditions, baseline mean arterial pressure (MAP) was 110+/-10 mm Hg and low-frequency fluctuations in BOLD signal were observed in the frequency range of 0.01 to 0.125 Hz. Following blood withdrawal (exsanguination), MAP decreased to 68+/-7 mm Hg, resulting in an increase in the amplitude of the low-frequency fluctuations in BOLD signal time series and an increase in power at several frequencies between 0.01 and 0.125 Hz. Spatially, the BOLD fluctuations were confined to the cortex and thalamus spanning both hemispheres with sparse presence in the caudate putamen and hippocampus during both normal and exsanguinated states. Spatial distribution of the low-frequency fluctuations in BOLD signal, from cross-correlation analysis, indicates substantial inter-hemispheric synchrony similar to that observed in the conscious human brain. The behavior of the resting state BOLD signal fluctuations similar to CBF fluctuations during exsanguination indicates a myogenic dependence. Also, a high inter-hemispheric synchrony combined with different phase characteristics of the low-frequency BOLD fluctuations particularly in the hippocampus relative to the cortex emphasizes distinct functional networks.
Authors:
Sridhar S Kannurpatti; Bharat B Biswal; Young Ro Kim; Bruce R Rosen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-06-27
Journal Detail:
Title:  NeuroImage     Volume:  40     ISSN:  1053-8119     ISO Abbreviation:  Neuroimage     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-14     Completed Date:  2008-06-23     Revised Date:  2014-05-26    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1738-47     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anesthesia*
Anesthetics, Inhalation*
Animals
Blood Pressure / drug effects
Brain / anatomy & histology*,  drug effects
Brain Chemistry / drug effects*
Cerebrovascular Circulation / drug effects,  physiology
Data Interpretation, Statistical
Functional Laterality / physiology
Hippocampus / anatomy & histology,  drug effects
Isoflurane*
Laser-Doppler Flowmetry
Magnetic Resonance Imaging
Male
Oxygen / blood*
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
NS-39044/NS/NINDS NIH HHS; R01 NS039044/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Anesthetics, Inhalation; CYS9AKD70P/Isoflurane; S88TT14065/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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