Document Detail

Spatially selective implementation of the adiabatic T2Prep sequence for magnetic resonance angiography of the coronary arteries.
MedLine Citation:
PMID:  22915337     Owner:  NLM     Status:  MEDLINE    
In coronary magnetic resonance angiography, a magnetization-preparation scheme for T2-weighting (T2Prep) is widely used to enhance contrast between the coronary blood-pool and the myocardium. This prepulse is commonly applied without spatial selection to minimize flow sensitivity, but the nonselective implementation results in a reduced magnetization of the in-flowing blood and a related penalty in signal-to-noise ratio. It is hypothesized that a spatially selective T2Prep would leave the magnetization of blood outside the T2Prep volume unaffected and thereby lower the signal-to-noise ratio penalty. To test this hypothesis, a spatially selective T2Prep was implemented where the user could freely adjust angulation and position of the T2Prep slab to avoid covering the ventricular blood-pool and saturating the in-flowing spins. A time gap of 150 ms was further added between the T2Prep and other prepulses to allow for in-flow of a larger volume of unsaturated spins. Consistent with numerical simulation, the spatially selective T2Prep increased in vivo human coronary artery signal-to-noise ratio (42.3 ± 2.9 vs. 31.4 ± 2.2, n = 22, P < 0.0001) and contrast-to-noise-ratio (18.6 ± 1.5 vs. 13.9 ± 1.2, P = 0.009) as compared to those of the nonselective T2Prep. Additionally, a segmental analysis demonstrated that the spatially selective T2Prep was most beneficial in proximal and mid segments where the in-flowing blood volume was largest compared to the distal segments.
Sahar Soleimanifard; Michael Schär; Allison G Hays; Jerry L Prince; Robert G Weiss; Matthias Stuber
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Publication Detail:
Type:  Journal Article; Research Support, American Recovery and Reinvestment Act; Research Support, N.I.H., Extramural     Date:  2012-08-22
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  70     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-24     Completed Date:  2014-01-30     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  97-105     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
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MeSH Terms
Blood Flow Velocity / physiology
Coronary Angiography / methods*
Coronary Circulation / physiology*
Coronary Vessels / anatomy & histology*,  physiology*
Image Enhancement / methods*
Image Interpretation, Computer-Assisted / methods*
Magnetic Resonance Angiography / methods*
Reproducibility of Results
Sensitivity and Specificity
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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