Document Detail

Spatially explicit prioritization of human antibiotics and antineoplastics in Europe.
MedLine Citation:
PMID:  23138017     Owner:  NLM     Status:  Publisher    
This paper presents a screening tool for the location-specific prioritization of human pharmaceutical emissions in Europe, based on risk quotients for the aquatic environment and human health. The tool provides direction towards either monitoring activities or additional research. Its application is illustrated for a set of 11 human antibiotics and 7 antineoplastics. Risk quotients for the aquatic environment were highest for levofloxacin, doxycycline and ciprofloxacin, located in Northern Italy (Milan region; particularly levofloxacin) and other densely populated areas in Europe (e.g. London, Krakow and the Ruhr area). Risk quotients for human health not only depend on pharmaceutical and location, but also on behavioral characteristics, such as consumption patterns. Infants in eastern Spain that consume locally produced food and conventionally treated drinking water were predicted to run the highest risks. A limited comparison with measured concentrations in surface water showed that predicted and measured concentrations are approximately within one order of magnitude.
Rik Oldenkamp; Mark A J Huijbregts; Anne Hollander; Ann Versporten; Herman Goossens; Ad M J Ragas
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-5
Journal Detail:
Title:  Environment international     Volume:  51C     ISSN:  1873-6750     ISO Abbreviation:  Environ Int     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7807270     Medline TA:  Environ Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  13-26     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Department of Environmental Science, Institute for Wetland and Water Research, Radboud University Nijmegen, P.O. Box 9010, 6500 GL Nijmegen, The Netherlands. Electronic address:
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