| Spatial tuning to sound source azimuth in the inferior colliculus of the unanesthetized rabbit. | |
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MedLine Citation:
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PMID: 21849611 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Despite decades of research devoted to the study of inferior colliculus (IC) neurons' tuning to sound-source azimuth, there remain many unanswered questions because no previous study examined azimuth tuning over a full range of 360° azimuths at a wide range of stimulus levels in an unanesthetized preparation. Furthermore, a comparison of azimuth tuning to binaural and contralateral-ear stimulation over ranges of full azimuths and widely varying stimulus levels was not previously reported. To fill this void, we conducted a study of azimuth tuning in the IC of the unanesthetized rabbit over a 300° range of azimuths at stimulus levels of 10-50 dB re: neural threshold to both binaural and contralateral-ear stimulation using virtual auditory space VAS stimuli. This study provides systematic evidence for neural coding of azimuth. We found the following: 1. Level tolerant azimuth tuning was observed in top 35% regarding vector strength and in the top 15% regarding vector angle of IC neurons. 2. Preserved azimuth tuning to binaural stimulation at high stimulus levels was created as a consequence of binaural facilitation in the contralateral sound field and binaural suppression in the ipsilateral sound field. 3. The direction of azimuth tuning to binaural stimulation was primarily in the contralateral sound field and its center shifted laterally towards -90° with increasing stimulus level. 4. At 10 dB, azimuth tuning to binaural and contralateral stimulation was similar indicating that it was mediated by monaural mechanisms. 5. At higher stimulus levels azimuth tuning to contralateral-ear stimulation was severely degraded. These findings form a foundation for understanding neural mechanisms of localizing sound-source azimuth. |
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Authors:
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Shigeyuki Kuwada; Brian Benjamin Bishop; Caitlin Alex; Daniel William Condit; Duck O Kim |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-17 |
Journal Detail:
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Title: Journal of neurophysiology Volume: - ISSN: 1522-1598 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375404 Medline TA: J Neurophysiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Connecticut Health Center. |
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