Document Detail

Spatial and topological distribution of progesterone receptor A and B isoforms during human development.
MedLine Citation:
PMID:  11500241     Owner:  NLM     Status:  MEDLINE    
Progesterone receptor (PR) is a member of the nuclear receptor superfamily. To date, two isoforms of PR have been identified, PR-A and PR-B. In progesterone responsive tissues, the relative ratio of PR-A and PR-B is considered to contribute to the tissue-specific actions of progesterone. In this study, we examined the distribution of PR-A and PR-B in human fetal tissues ranging from 11 to 40 gestational weeks using immunohistochemistry and RT-PCR analysis. PR immunoreactivity was detected in a wide range of fetal tissues until 20 weeks of gestation, but gradually decreased towards the late gestational period. However, PR continued to remain positive throughout the gestational period in the interstitial cells of Cajal and endocrine tissues. PR-B was demonstrated as the predominant isoform in comparison to PR-A in all fetal tissues examined. These findings suggest that progesterone may be involved in the development of fetal organs throughout the gestational period.
T Inoue; J I Akahira; J Takeyama; T Suzuki; A D Darnel; C Kaneko; Y Kurokawa; S Satomi; H Sasano
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  182     ISSN:  0303-7207     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-13     Completed Date:  2001-12-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  83-9     Citation Subset:  IM    
Department of Pathology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980 8575, Japan.
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MeSH Terms
Embryonic and Fetal Development*
Enteroendocrine Cells / chemistry
Fetus / cytology,  metabolism,  physiology
Gestational Age
Intestines / cytology,  embryology
Protein Isoforms / genetics,  metabolism,  physiology
RNA, Messenger / metabolism
Receptors, Progesterone / genetics,  metabolism*,  physiology
Reverse Transcriptase Polymerase Chain Reaction
Tissue Distribution
Reg. No./Substance:
0/Protein Isoforms; 0/RNA, Messenger; 0/Receptors, Progesterone; 0/progesterone receptor A; 0/progesterone receptor B

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