Document Detail


Spatial and temporal organization of pressure patterns throughout the unprepared colon during spontaneous defecation.
MedLine Citation:
PMID:  10763955     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The aim of this study was to examine colonic motor events associated with spontaneous defecation in the entire unprepared human colon under physiological conditions. METHODS: In 13 healthy volunteers a perfused, balloon-tipped, 17-lumen catheter (outer diameter, 3.5 mm; intersidehole spacing, 7.5 cm) was passed pernasally and positioned in the distal unprepared colon. RESULTS: In the hour before spontaneous defecation, there was an increase in propagating sequence frequency (p = 0.04) and nonpropagating activity when compared to basal conditions (p < 0.0001). During this hour the spatial and temporal relationships among propagating sequences demonstrated a biphasic pattern. Both the early (proximal) and late (distal) colonic phases involved the whole colon and were characterized by respective antegrade and retrograde migration of site-of-origin of arrays of propagating sequences. There was a negative correlation between propagating sequence amplitude and the time interval from propagating sequence to stool expulsion (p = 0.008). CONCLUSIONS: The colonic motor correlate of defecation is the colonic propagating sequence, the frequency and amplitude of which begin to increase as early as 1 h before stool expulsion. During the preexpulsive phase, the spatial and temporal relationship among the sites of origin of individual propagating sequences demonstrate a stereotypic anal followed by orad migration, which raises the possibility of control by long colocolonic pathways.
Authors:
P A Bampton; P G Dinning; M L Kennedy; D Z Lubowski; D deCarle; I J Cook
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  95     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-04-25     Completed Date:  2000-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1027-35     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, The St. George Hospital, University of New South Wales, Kogarah, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Colon / physiology*
Defecation / physiology*
Female
Gastrointestinal Motility / physiology
Gastrointestinal Transit / physiology
Humans
Male
Manometry
Reference Values

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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