Document Detail

Spatial and temporal measurements of temperature and cell viability in response to nanoparticle-mediated photothermal therapy.
MedLine Citation:
PMID:  22812710     Owner:  NLM     Status:  Publisher    
Aim: Nanoparticle-enhanced photothermal therapy is a promising alternative to tumor resection. However, quantitative measurements of cellular response to these treatments are limited. This article introduces a Bimodal Enhanced Analysis of Spatiotemporal Temperature (BEAST) algorithm to rapidly determine the viability of cancer cells in vitro following photothermal therapy alone or in combination with nanoparticles. Materials & methods: To illustrate the capability of the BEAST viability algorithm, single wall carbon nanohorns were added to renal cancer (RENCA) cells in vitro and time-dependent spatial temperature maps measured with an infrared camera during laser therapy were correlated with post-treatment cell viability distribution maps obtained by cell-staining fluorescent microscopy. Conclusion: The BEAST viability algorithm accurately and rapidly determined the cell viability as a function of time, space and temperature. Original submitted 13 July 2011; Revised submitted 12 March 2012.
Jon R Whitney; Amanda Rodgers; Erica Harvie; William F Carswell; Suzy Torti; Alex A Puretzky; Christopher M Rouleau; David B Geohegan; Christopher G Rylander; Marissa N Rylander
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-20
Journal Detail:
Title:  Nanomedicine (London, England)     Volume:  -     ISSN:  1748-6963     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101278111     Medline TA:  Nanomedicine (Lond)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Mechanical Engineering & School of Biomedical Engineering & Sciences, Virginia Tech, VA 24061, USA: ICTAS 410 ICTAS, Stanger Street (MC 0193) Blacksburg, VA 24061, USA.
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