| Spatial and temporal localisation of bone morphogenetic protein-3 (osteogenin) in the developing rat submandibular gland. | |
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MedLine Citation:
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PMID: 12625183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Submandibular gland morphogenesis is a highly regulated process modulated by epithelio-mesenchymal interactions. Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF-beta) superfamily, are known to be soluble mediators of epithelio-mesenchymal interactions during the development of certain organs. The aim of this study was to localise bone morphogenetic protein-3 (BMP-3 or osteogenin), spatially and temporally in the developing rat submandibular gland. Immunocytochemistry was performed on sections of the developing submandibular gland (gestation ages E14.5-E19.5). BMP-3 was localised in the extra-cellular matrix of the mesenchyme of the gland in all the stages examined. Intense staining of BMP-3 was observed in the epithelial cells of the developing end-buds between stages E14.5 and E16.5. As cytodifferentiation progressed (stage E17.5 onwards) the number of epithelial cells in the developing acini in which BMP-3 was present became markedly reduced. Similarly, the number of cells containing BMP-3 in the developing ducts decreased as duct development progressed. By stage E19.5, BMP-3 was located mainly in the immature ducts. While the effects of BMP-3 on matrix macromolecules could not be deduced from this study, its spatial and temporal location within the developing glands may indicate a role in the co-ordinated regulation of branching morphogenesis. |
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Authors:
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G Hardy; B Kramer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging Volume: 55 ISSN: 1029-4864 ISO Abbreviation: SADJ Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2003-03-10 Completed Date: 2003-04-02 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9812497 Medline TA: SADJ Country: South Africa |
Other Details:
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Languages: eng Pagination: 136-41 Citation Subset: D |
Affiliation:
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Department of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown 2193, Johannesburg, South Africa. 055bevk@chiron.wits.ac.za |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Morphogenetic Protein 3 Bone Morphogenetic Proteins / analysis* Cell Differentiation Coloring Agents / diagnostic use Epithelial Cells / metabolism Epithelium / embryology Extracellular Matrix / metabolism Fetus Fluorescent Dyes / diagnostic use Gestational Age Growth Substances / analysis* Immunohistochemistry Mesoderm / metabolism Morphogenesis / physiology Rats Rats, Sprague-Dawley Salivary Ducts / embryology Submandibular Gland / embryology* |
| Chemical | |
Reg. No./Substance:
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0/Bmp3 protein, rat; 0/Bone Morphogenetic Protein 3; 0/Bone Morphogenetic Proteins; 0/Coloring Agents; 0/Fluorescent Dyes; 0/Growth Substances |
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