Document Detail

Spatial and temporal changes of chlorinated pesticides, PCBs, dioxins (PCDDs/PCDFs) and brominated flame retardants in human breast milk from Northern Russia.
MedLine Citation:
PMID:  18063018     Owner:  NLM     Status:  MEDLINE    
This study presents for the first time temporal changes of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in Russian human breast milk samples. Concentrations of OCPs and PCBs in samples from three locations in the North West of Russia in 2000-2002 (n=42), were compared to corresponding levels measured in 1993-1996 (n=58). In addition brominated flame retardants (BFRs), consisting of polybrominated diphenylethers (PBDEs) (including BDE-209) and hexabromocyclododecane (HBCD) were analysed in samples from 2000-2002 (n=37). The present levels of SigmaDDTs and SigmaHCHs were 5 and 10 times higher than corresponding levels in the neighbouring country Norway. Median concentrations of SigmaHCHs (196 microg/kg lw), SigmaCHBs (19.7 microg/kg lw) and SigmaPCBs(16) (316 microg/kg lw) were highest in Murmansk. The percentage of p,p'-DDT to SigmaDDTs and ratio DDE/DDT suggest possible ongoing use of DDT in Russia. Levels of PBDE were low and dominated by the congeners BDE-47 and BDE-153. The deca brominated BDE-209 was detected in all analysed samples (median concentration 0.19 microg/kg lipid). Levels of SigmaOCPs and SigmaPCBs decreased 56 and 30% in Murmansk and 36 and 43% in Arkhangelsk during the study period. The decline of SigmaOCPs was significant at both locations (p<0.05-p<0.0001). For SigmaPCBs, the decreasing trend was only significant in Arkhangelsk (p<0.0001). In addition, a decline of Sigmatotal TEQs (SigmaTEQs of PCDDs/PCDFs, non-ortho- and mono-ortho PCBs) was observed in Murmansk and Arkhangelsk during the study period. The exposure of infants by PCDDs/PCDFs and dioxin-like PCBs is still exceeding the daily tolerable intake (TDI) in North West Russia. However, the concentrations of PCDDs/PCDFs and dioxin-like PCBs seem to decline very rapidly.
A Polder; G W Gabrielsen; J Ø Odland; T N Savinova; A Tkachev; K B Løken; J U Skaare
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-11
Journal Detail:
Title:  The Science of the total environment     Volume:  391     ISSN:  0048-9697     ISO Abbreviation:  Sci. Total Environ.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2007-12-25     Completed Date:  2008-04-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0330500     Medline TA:  Sci Total Environ     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  41-54     Citation Subset:  IM    
The Norwegian School of Veterinary Science, Oslo, Norway.
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MeSH Terms
Benzofurans / metabolism
Body Burden
Environmental Monitoring
Environmental Pollutants / metabolism*
Flame Retardants / metabolism
Hydrocarbons, Brominated / metabolism
Hydrocarbons, Chlorinated / metabolism
Infant, Newborn
Maternal Exposure*
Milk, Human / chemistry*
Pesticides / metabolism
Phenyl Ethers / metabolism
Polybrominated Biphenyls / metabolism
Tetrachlorodibenzodioxin / analogs & derivatives,  metabolism
Reg. No./Substance:
0/Benzofurans; 0/Environmental Pollutants; 0/Flame Retardants; 0/Hydrocarbons, Brominated; 0/Hydrocarbons, Chlorinated; 0/Pesticides; 0/Phenyl Ethers; 0/Polybrominated Biphenyls; 0/chlorinated dibenzofurans; 0/polychlorodibenzo-4-dioxin; 1746-01-6/Tetrachlorodibenzodioxin; 25637-99-4/hexabromocyclododecane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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