| Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy. | |
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MedLine Citation:
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PMID: 20865701 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Advanced cerebrovascular β-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined. We used T2*-weighted magnetic resonance imaging (MRI) and noninvasive amyloid imaging with Pittsburgh Compound B (PiB) to analyze the spatial relationship between CAA and microbleeds. On coregistered positron emission tomography (PET) and MRI images, PiB retention was increased at microbleed sites compared to simulated control lesions (p = 0.002) and declined with increasing distance from the microbleed (p < 0.0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition. |
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Authors:
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Gregory A Dierksen; Maureen E Skehan; Muhammad A Khan; Jed Jeng; R N Kaveer Nandigam; John A Becker; Ashok Kumar; Krista L Neal; Rebecca A Betensky; Matthew P Frosch; Jonathan Rosand; Keith A Johnson; Anand Viswanathan; David H Salat; Steven M Greenberg |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of neurology Volume: 68 ISSN: 1531-8249 ISO Abbreviation: Ann. Neurol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-26 Completed Date: 2010-11-12 Revised Date: 2012-04-27 |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 545-8 Citation Subset: IM |
Affiliation:
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Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amyloid / metabolism* Aniline Compounds / diagnostic use Cerebral Amyloid Angiopathy / complications*, metabolism*, pathology, radionuclide imaging Female Humans Intracranial Hemorrhages / etiology* Magnetic Resonance Imaging / methods Male Middle Aged Positron-Emission Tomography / methods Thiazoles / diagnostic use |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG026484/AG/NIA NIH HHS; R01 AG026484-04/AG/NIA NIH HHS; R01 AG026484-07/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; 0/Amyloid; 0/Aniline Compounds; 0/Thiazoles |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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