Document Detail


Spatial regulators for bacterial cell division self-organize into surface waves in vitro.
MedLine Citation:
PMID:  18467587     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the bacterium Escherichia coli, the Min proteins oscillate between the cell poles to select the cell center as division site. This dynamic pattern has been proposed to arise by self-organization of these proteins, and several models have suggested a reaction-diffusion type mechanism. Here, we found that the Min proteins spontaneously formed planar surface waves on a flat membrane in vitro. The formation and maintenance of these patterns, which extended for hundreds of micrometers, required adenosine 5'-triphosphate (ATP), and they persisted for hours. We present a reaction-diffusion model of the MinD and MinE dynamics that accounts for our experimental observations and also captures the in vivo oscillations.
Authors:
Martin Loose; Elisabeth Fischer-Friedrich; Jonas Ries; Karsten Kruse; Petra Schwille
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  320     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-09     Completed Date:  2008-05-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  789-92     Citation Subset:  IM    
Affiliation:
Biotechnologisches Zentrum der Technischen Universität Dresden, Tatzberg 47-51, 01307 Dresden, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphatases / physiology*
Adenosine Triphosphate / physiology
Bacterial Proteins
Cell Cycle Proteins / physiology*
Cell Division / physiology*
Cell-Free System
Cytoskeletal Proteins
Diffusion
Escherichia coli / physiology*
Escherichia coli Proteins / physiology*
Models, Biological
Oscillometry
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/Cell Cycle Proteins; 0/Cytoskeletal Proteins; 0/Escherichia coli Proteins; 0/FtsZ protein, Bacteria; 0/MinE protein, E coli; 56-65-5/Adenosine Triphosphate; EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.1.-/MinD protein, E coli
Comments/Corrections
Comment In:
Science. 2008 May 9;320(5877):755-6   [PMID:  18467579 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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