Document Detail

Spatial regulators for bacterial cell division self-organize into surface waves in vitro.
MedLine Citation:
PMID:  18467587     Owner:  NLM     Status:  MEDLINE    
In the bacterium Escherichia coli, the Min proteins oscillate between the cell poles to select the cell center as division site. This dynamic pattern has been proposed to arise by self-organization of these proteins, and several models have suggested a reaction-diffusion type mechanism. Here, we found that the Min proteins spontaneously formed planar surface waves on a flat membrane in vitro. The formation and maintenance of these patterns, which extended for hundreds of micrometers, required adenosine 5'-triphosphate (ATP), and they persisted for hours. We present a reaction-diffusion model of the MinD and MinE dynamics that accounts for our experimental observations and also captures the in vivo oscillations.
Martin Loose; Elisabeth Fischer-Friedrich; Jonas Ries; Karsten Kruse; Petra Schwille
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  320     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-09     Completed Date:  2008-05-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  789-92     Citation Subset:  IM    
Biotechnologisches Zentrum der Technischen Universität Dresden, Tatzberg 47-51, 01307 Dresden, Germany.
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MeSH Terms
Adenosine Triphosphatases / physiology*
Adenosine Triphosphate / physiology
Bacterial Proteins
Cell Cycle Proteins / physiology*
Cell Division / physiology*
Cell-Free System
Cytoskeletal Proteins
Escherichia coli / physiology*
Escherichia coli Proteins / physiology*
Models, Biological
Reg. No./Substance:
0/Bacterial Proteins; 0/Cell Cycle Proteins; 0/Cytoskeletal Proteins; 0/Escherichia coli Proteins; 0/FtsZ protein, Bacteria; 0/MinE protein, E coli; 56-65-5/Adenosine Triphosphate; EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.1.-/MinD protein, E coli
Comment In:
Science. 2008 May 9;320(5877):755-6   [PMID:  18467579 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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