Document Detail


Spatial regulation of exocytosis and cell polarity: yeast as a model for animal cells.
MedLine Citation:
PMID:  17418146     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exocytosis is the major mechanism by which new membrane components are delivered to the cell surface. In most, if not all, eukaryotic cells this is also a highly spatially regulated process that is tightly coordinated with the overall polarity of a cell. The Rho/Cdc42 family of GTPases and the lethal giant larvae/Sro7 family are two highly conserved families of proteins which appear to have dual functions both in cell polarity and exocytosis. Analysis of their functions has begun to unravel the coordination between these processes and propose a model for polarized vesicle docking and fusion at the site of asymmetric cell growth.
Authors:
Patrick Brennwald; Guendalina Rossi
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-03-30
Journal Detail:
Title:  FEBS letters     Volume:  581     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-14     Completed Date:  2007-07-24     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2119-24     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adaptor Proteins, Signal Transducing
Animals
Carrier Proteins / metabolism
Cell Polarity*
Exocytosis / physiology*
Saccharomyces cerevisiae / cytology,  physiology*
Saccharomyces cerevisiae Proteins / metabolism
cdc42 GTP-Binding Protein / metabolism
rho GTP-Binding Proteins / metabolism
Grant Support
ID/Acronym/Agency:
R01 GM054712/GM/NIGMS NIH HHS; R01 GM054712-11/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/Carrier Proteins; 0/SRO7 protein, S cerevisiae; 0/Saccharomyces cerevisiae Proteins; EC 3.6.5.2/cdc42 GTP-Binding Protein; EC 3.6.5.2/rho GTP-Binding Proteins
Comments/Corrections

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