| Spatial heterogeneity in VEGF-induced vasodilation: VEGF dilates microvessels but not epicardial and systemic arteries and veins. | |
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MedLine Citation:
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PMID: 12704544 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to investigate the site of vascular endothelial growth factor (VEGF)-induced vasodilation in the systemic and coronary vasculature. Intracoronary infusion of VEGF in Yorkshire pigs resulted in a significant drop in the mean arterial blood pressure, with a decline in the left ventricular left end-diastolic pressure, and no change in the heart rate. Coronary blood flow increase after intracoronary infusion of 10 mg VEGF (2.63 +/- 0.49x) was comparable to that seen after 40 mg of intracoronary adenosine (2.5 +/- 0.53x, p = 0.67) and was significantly higher then after 200 mg of intracoronary nitroglycerine (1.9 +/- 0.12x, p = 0.0005). At the same time, intracoronary VEGF did not result in a significant increase in coronary cross-sectional area determined using intravascular ultrasound. In vitro, VEGF produced dose-dependent relaxation of myocardial and systemic arterioles and venules (arterioles: 60-100 mm and venules: 120-200 mm in internal diameter) that was partially inhibited by L-NNA, but had no effect on epicardial coronary arteries, systemic arteries, or veins. Both VEGF receptors (flt-1 and flk-1) were identified on endothelial cells of epicardial arteries and veins. We conclude that this spatial heterogeneity of VEGF vasomotor effects cannot be explained by the absence VEGF receptors and suggests differential patterns of signal transduction in the vascular tree. |
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Authors:
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Roger J Laham; Jian Li; Motohisa Tofukuji; Mark Post; Michael Simons; Frank W Sellke |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2003-04-22 |
Journal Detail:
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Title: Annals of vascular surgery Volume: 17 ISSN: 0890-5096 ISO Abbreviation: Ann Vasc Surg Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-06-05 Completed Date: 2003-10-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8703941 Medline TA: Ann Vasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 245-52 Citation Subset: IM |
Affiliation:
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Angiogenesis Research Center, Department of Medicine and Surgery, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. rlaham@bidmc.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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pharmacology Animals Arteries / drug effects Endothelial Growth Factors / pharmacology* Female Hemodynamics / drug effects Intercellular Signaling Peptides and Proteins / pharmacology* Lymphokines / pharmacology* Male Microcirculation / drug effects* Nitroglycerin / pharmacology Signal Transduction / physiology Swine Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Vasodilation / drug effects* Vasodilator Agents / pharmacology* Veins / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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HL 46716/HL/NHLBI NIH HHS; HL 63609/HL/NHLBI NIH HHS; M01-RR01032/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Endothelial Growth Factors; 0/Intercellular Signaling Peptides and Proteins; 0/Lymphokines; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors; 0/Vasodilator Agents; 55-63-0/Nitroglycerin; 58-61-7/Adenosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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