| Spatial expression of the genome: the signal hypothesis at forty. | |
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MedLine Citation:
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PMID: 21487438 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The signal hypothesis, formulated by Günter Blobel and David Sabatini in 1971, and elaborated by Blobel and his colleagues between 1975 and 1980, fundamentally expanded our view of cells by introducing the concept of topogenic signals. Cells were no longer just morphological entities with compartmentalized biochemical functions; they were now active participants in the creation and perpetuation of their own form and identity, the decoders of linear genetic information into three dimensions. |
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Authors:
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Karl S Matlin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-04-13 |
Journal Detail:
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Title: Nature reviews. Molecular cell biology Volume: 12 ISSN: 1471-0080 ISO Abbreviation: Nat. Rev. Mol. Cell Biol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-21 Completed Date: 2011-07-22 Revised Date: 2012-01-27 |
Medline Journal Info:
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Nlm Unique ID: 100962782 Medline TA: Nat Rev Mol Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 333-40 Citation Subset: IM |
Affiliation:
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Department of Surgery, The University of Chicago, 5841 South Maryland Avenue, MC 5032, SBRI J557, Chicago, Illinois 60637-1470, USA. kmatlin@uchicago.edu. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Endoplasmic Reticulum
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metabolism* Models, Genetic Protein Biosynthesis / genetics* Protein Sorting Signals / genetics* Ribosomes / metabolism* Signal Transduction / genetics |
| Grant Support | |
ID/Acronym/Agency:
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G13 LM009860-02/LM/NLM NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Protein Sorting Signals |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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