| Spatial distribution of white-matter hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging. | |
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MedLine Citation:
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PMID: 18292383 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: White-matter hyperintensities (WMHs) detected by magnetic resonance imaging are thought to represent the effects of cerebral small-vessel disease and neurodegenerative changes. We sought to determine whether the spatial distribution of WMHs discriminates between different disease groups and healthy aging individuals and whether these distributions are related to local cerebral perfusion patterns. METHODS: We examined the pattern of WMHs by T2/fluid-attenuated inversion recovery-weighted magnetic resonance imaging in 3 groups of subjects: cerebral amyloid angiopathy (n=32), Alzheimer disease or mild cognitive impairment (n=41), and healthy aging (n=29). WMH frequency maps were calculated for each group, and spatial distributions were compared by voxel-wise logistic regression. WMHs were also analyzed as a function of normal cerebral perfusion patterns by overlaying a single photon emission computed tomography atlas. RESULTS: Although WMH volume was greater in cerebral amyloid angiopathy and Alzheimer disease/mild cognitive impairment than in healthy aging, there was no consistent difference in the spatial distributions when controlling for total WMH volume. Hyperintensities were most frequent in the deep periventricular WM in all 3 groups. A strong inverse correlation between hyperintensity frequency and normal perfusion was demonstrated in all groups, demonstrating that WMHs were most common in regions of relatively lower normal cerebral perfusion. CONCLUSIONS: WMHs show a common distribution pattern and predilection for cerebral WM regions with lower atlas-derived perfusion, regardless of the underlying diagnosis. These data suggest that across diverse disease processes, WM injury may occur in a pattern that reflects underlying tissue properties, such as relative perfusion. |
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Authors:
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Christopher M Holland; Eric E Smith; Istvan Csapo; Mahmut Edip Gurol; Douglas A Brylka; Ronald J Killiany; Deborah Blacker; Marilyn S Albert; Charles R G Guttmann; Steven M Greenberg |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-02-21 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 39 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-25 Completed Date: 2008-04-23 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 1127-33 Citation Subset: IM |
Affiliation:
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Center for Neurological Imaging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Aging / pathology* Alzheimer Disease / pathology*, radionuclide imaging Cerebral Amyloid Angiopathy / pathology*, radionuclide imaging Cerebrovascular Circulation Cognition Disorders / pathology, radionuclide imaging Female Humans Magnetic Resonance Imaging* Male Nerve Fibers, Myelinated / pathology*, radionuclide imaging Tomography, Emission-Computed, Single-Photon |
| Grant Support | |
ID/Acronym/Agency:
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F30 NS049808/NS/NINDS NIH HHS; F30 NS049808-01A2/NS/NINDS NIH HHS; F30 NS049808-02/NS/NINDS NIH HHS; F30 NS049808-03/NS/NINDS NIH HHS; K24 NS056207/NS/NINDS NIH HHS; K24 NS056207-01/NS/NINDS NIH HHS; K24 NS056207-02/NS/NINDS NIH HHS; K24 NS056207-03/NS/NINDS NIH HHS; K24 NS056207-04/NS/NINDS NIH HHS; P01 AG004953-190006/AG/NIA NIH HHS; P01 AG004953-200006/AG/NIA NIH HHS; P01 AG004953-210006/AG/NIA NIH HHS; P01 AG004953-220006/AG/NIA NIH HHS; P01 AG004953-230006/AG/NIA NIH HHS; P01 AG04953/AG/NIA NIH HHS; P41 RR013218-010009/RR/NCRR NIH HHS; P41 RR13218-01/RR/NCRR NIH HHS; R01 AG026484/AG/NIA NIH HHS; R01 AG026484-01/AG/NIA NIH HHS; R01 AG026484-02/AG/NIA NIH HHS; R01 AG026484-03/AG/NIA NIH HHS; R01 AG026484-04/AG/NIA NIH HHS; R01 AG026484-05/AG/NIA NIH HHS |
| Comments/Corrections | |
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