Document Detail


Spatial distribution of phase singularities in ventricular fibrillation.
MedLine Citation:
PMID:  12835210     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Multiple excitation wavelets are present during ventricular fibrillation (VF). The underlying wavelet organization of VF is unclear. Phase singularities (PSs)-locations of ambiguous activation state-underlie reentry and wavelet splitting and represent the sources of VF. Understanding the mechanisms of PS formation might be important in the development of effective therapies for sudden death. METHODS AND RESULTS: We performed voltage, phase, and PS mapping in fibrillating ventricles, applying an automated PS detection algorithm to optically recorded fibrillation signals. PS clustering was noted along epicardial vessels, ridges of endocardial trabeculae, and papillary muscle insertions. Microscopically, these locations correlated with areas of apposition of fibers with different angulations and intramural vessels. A total of 83.2% of PSs were formed at and meandered about these anatomic structures, which acted as stabilizers: PSs colocalizing at anatomic substrates had longer life spans than nonanatomic PS (82.46+/-60.8 versus 40.5+/-31.9 ms, P<0.01). The RV endocardium had a higher PS incidence than the epicardium (42.3+/-9.2 versus 23.5+/-11.6 PS/s, P<0.01). Autocorrelation showed that irregular behavior was spatially restricted to anatomic heterogeneities compared with other areas, which had nearly periodic behaviors. Simple spatial PS distributions underlay complex and variable activation patterns attributable to variable PS behaviors, life spans, and inter-PS interactions. CONCLUSIONS: PSs occur in a nonrandom spatial distribution and colocalize with normal anatomic heterogeneities. Varying PS behaviors and life spans but stable PS spatial distributions cause ever-changing activation patterns that characterize VF.
Authors:
Miguel Valderrábano; Peng-Sheng Chen; Shien-Fong Lin
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2003-06-30
Journal Detail:
Title:  Circulation     Volume:  108     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-23     Completed Date:  2003-08-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  354-9     Citation Subset:  AIM; IM    
Affiliation:
Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center and David Geffen School of Medicine, University of California Los Angeles, Calif 90048, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Clocks
Body Surface Potential Mapping
Electrophysiologic Techniques, Cardiac / methods*
Heart / physiopathology*
Heart Conduction System / physiopathology*
Optics and Photonics
Periodicity
Rabbits
Time Factors
Ventricular Fibrillation / physiopathology*
Grant Support
ID/Acronym/Agency:
P50HL52319/HL/NHLBI NIH HHS; R01HL 71140/HL/NHLBI NIH HHS; R01HL58533/HL/NHLBI NIH HHS; R01HL66389/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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