Document Detail

Spatial coding of visually guided arm movements in primate motor cortex.
MedLine Citation:
PMID:  3167679     Owner:  NLM     Status:  MEDLINE    
Previous studies of the motor cortex in behaving animals were focused on the relations between the activity of single cells, usually pyramidal tract neurons, and parameters of isometric contraction (e.g., intensity of force) or parameters of movement along one axis (e.g., flexion-extension) of a single joint (e.g., elbow or wrist). However, the commonly meaningful behavioral parameter is the trajectory of the hand in extrapersonal space, which is realized by simultaneous motions about two or three joints (e.g., elbow, shoulder, wrist) and concurrent engagement of several muscles. The spatial parameters of a straight trajectory are its direction and extent. We hypothesized that a major function of the motor cortex, among other possible roles, is the specification and control of the direction of the movement trajectory in space. This reference of motor cortical function to the control of spatial aspects of the trajectory differentiated our approach from the other approaches outlined above. We investigated the directional selectivity cells in the arm area of the motor cortex by recording their activity while monkeys moved their hands in various directions in space towards visual targets. There were two salient findings of these studies. First, the intensity of the discharge of single cells varies in an orderly fashion with the direction of movement in space, so that the discharge rate is highest with movements in a preferred direction, and decreases progressively with movements made in directions more and more away from the preferred one. Thus single cells are broadly tuned around a preferred direction which differs among different cells.(ABSTRACT TRUNCATED AT 250 WORDS)
A P Georgopoulos
Related Documents :
2934519 - Trained slow tracking. ii. bidirectional discharge patterns of cerebellar nuclear, moto...
15128859 - Behavioral context and coherent oscillations in the supplementary motor area.
15908949 - Instructive signals for motor learning from visual cortical area mt.
2224509 - Delay, discriminatory, and modality specific neurons in striatum and pallidum during sh...
23752309 - Nadh-dehydrogenase type-2 suppresses irreversible visual loss and neurodegeneration in ...
12232689 - Timing of bimanual movements in human and non-human primates in relation to neuronal ac...
10797549 - Localization of bcl-xbeta in the developing and adult rat central nervous system.
22367679 - Roles of activated microglia in hypoxia induced neuroinflammation in the developing bra...
22484379 - Tonic and phasic drive to medullary respiratory neurons during periodic breathing.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  66     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-11-01     Completed Date:  1988-11-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  518-26     Citation Subset:  IM; S    
Philip Bard Laboratories of Neurophysiology, Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD 21205.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arm / physiology*
Motor Cortex / physiology*
Neurons / physiology
Primates / physiology*
Psychomotor Performance / physiology*
Space Perception / physiology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Planning and execution of multijoint movements.
Next Document:  Models of sensorimotor transformations and vestibular reflexes.