Document Detail


Spasticity causes a fundamental rearrangement of muscle-joint interaction.
MedLine Citation:
PMID:  11870696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sarcomere length was measured in flexor carpi ulnaris (FCU) muscles from patients with severely spastic wrist flexion contractures (n = 6), as well as from patients with radial nerve injury and a normally innervated FCU (n = 12). Spastic FCU muscles had extremely long sarcomere lengths with the wrist fully flexed (3.48 +/- 0.44 microm) compared to the FCU muscles of patients with radial nerve injury (2.41 +/- 0.31 microm). In three of the patients with spastic wrist flexion contractures, the slope of the FCU sarcomere length-joint angle relationship was measured and found to be, essentially, normal (0.017 +/- 0.005 microm/degree, n = 3) suggesting that serial sarcomere number (and therefore muscle fiber length) was unchanged in spite of the dramatic absolute sarcomere length change. These results indicate that spasticity results in a major alteration of normal muscle-joint anatomical relationships that has not previously been recognized to our knowledge. We hypothesize that the results are explained either by the inability of muscle fibers to add serial sarcomeres in response to growth, or the selective loss of FCU muscle length secondary to the central nervous system lesion.
Authors:
Richard L Lieber; Jan Fridén
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Muscle & nerve     Volume:  25     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-28     Completed Date:  2002-03-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  265-70     Citation Subset:  IM    
Copyright Information:
Copyright 2002 John Wiley & Sons, Inc.
Affiliation:
Department of Orthopaedics, University of California and Veterans Administration Medical Centers, 3350 La Jolla Village Drive, San Diego, California 92161, USA. rlieber@ucsd.edu
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Adolescent
Adult
Contracture / physiopathology
Female
Humans
Joints / physiopathology*
Male
Muscle Spasticity / pathology,  physiopathology*
Muscle, Skeletal / pathology,  physiopathology*
Radial Nerve / injuries
Sarcomeres / pathology
Wounds and Injuries / pathology
Wrist / physiopathology
Grant Support
ID/Acronym/Agency:
45339//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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