Document Detail


Spastic diplegia as a complication of interferon Alfa-2a treatment of hemangiomas of infancy.
MedLine Citation:
PMID:  9544915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the development of spastic diplegia in infants during the course of interferon Alfa-2a (IFN) therapy for potentially life-endangering hemangiomas. Five infants who displayed diplegia were selected from a group of 26 infants treated with IFN. Diplegia persisted in three infants, and in the remaining two significant recovery occurred after IFN was discontinued. Magnetic resonance imaging showed no significant brain or spinal abnormalities except minor to moderate delayed myelination in two patients. Myelination was normal on subsequent radiographic examination in all five patients. We conclude that IFN can adversely affect the immature central nervous system and produce spastic diplegia, which is potentially reversible. We recommend careful clinical assessment of neurodevelopmental status during IFN therapy.
Authors:
C F Barlow; C J Priebe; J B Mulliken; P D Barnes; D Mac Donald; J Folkman; R A Ezekowitz
Related Documents :
3089015 - Pregnancy events and brain damage.
23870985 - Characterisation and optimisation of physical and oxidative stability of structured lip...
15597195 - Cd15 immunoreactivity in the developing brain of a marsupial, the tammar wallaby ( macr...
22424375 - Congenital pancreatic cyst with ivemark ii syndrome: a rare case.
25459495 - When should automatic auditory brainstem response test be used for newborn hearing scre...
19922725 - Born a bit too early: recent trends in late preterm births.
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  132     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-04-28     Completed Date:  1998-04-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  527-30     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology, Children's Hospital, Boston, Massachusetts, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cerebral Palsy / etiology*,  physiopathology
Female
Hemangioma / therapy*
Humans
Infant, Newborn
Interferon Alfa-2a / adverse effects*
Magnetic Resonance Imaging
Grant Support
ID/Acronym/Agency:
M01 RR02172/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
76543-88-9/Interferon Alfa-2a
Comments/Corrections
Comment In:
J Pediatr. 1999 Mar;134(3):382   [PMID:  10064684 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Calibrated-orifice nipples for measurement of infant nutritive sucking.
Next Document:  Increased risk of spastic diplegia among very low birth weight children after preterm labor or prela...