Document Detail

Spastic diplegia as a complication of interferon Alfa-2a treatment of hemangiomas of infancy.
MedLine Citation:
PMID:  9544915     Owner:  NLM     Status:  MEDLINE    
We report the development of spastic diplegia in infants during the course of interferon Alfa-2a (IFN) therapy for potentially life-endangering hemangiomas. Five infants who displayed diplegia were selected from a group of 26 infants treated with IFN. Diplegia persisted in three infants, and in the remaining two significant recovery occurred after IFN was discontinued. Magnetic resonance imaging showed no significant brain or spinal abnormalities except minor to moderate delayed myelination in two patients. Myelination was normal on subsequent radiographic examination in all five patients. We conclude that IFN can adversely affect the immature central nervous system and produce spastic diplegia, which is potentially reversible. We recommend careful clinical assessment of neurodevelopmental status during IFN therapy.
C F Barlow; C J Priebe; J B Mulliken; P D Barnes; D Mac Donald; J Folkman; R A Ezekowitz
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  132     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-04-28     Completed Date:  1998-04-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  527-30     Citation Subset:  AIM; IM    
Department of Neurology, Children's Hospital, Boston, Massachusetts, USA.
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MeSH Terms
Cerebral Palsy / etiology*,  physiopathology
Hemangioma / therapy*
Infant, Newborn
Interferon Alfa-2a / adverse effects*
Magnetic Resonance Imaging
Grant Support
Reg. No./Substance:
76543-88-9/Interferon Alfa-2a
Comment In:
J Pediatr. 1999 Mar;134(3):382   [PMID:  10064684 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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