Document Detail

Spasmolytic effects of cadmium and zinc ions upon the guinea-pig isolated ileum preparation.
MedLine Citation:
PMID:  4396970     Owner:  NLM     Status:  MEDLINE    
1. An investigation has been made of the effects of cadmium and zinc ions upon the contractile response of the guinea-pig isolated ileum to methacholine, histamine, potassium ion and a.c. field stimulation. The metal ions depress the response to all of these agents.2. Radioisotope studies showed that cadmium and zinc ions have very much larger apparent volumes of distribution than sorbitol, both within whole ileum and within strips of the longitudinal smooth muscle layer. The results of these studies were indicative of surface binding and/or intracellular accumulation of these ions.3. It is suggested that cadmium and zinc ions directly depress smooth muscle contractility in a non-specific manner. This action may result from their binding to or accumulation within the muscle cells.
H Schnieden; R C Small
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  41     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1971 Mar 
Date Detail:
Created Date:  1971-07-06     Completed Date:  1971-07-06     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  488-99     Citation Subset:  IM    
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MeSH Terms
Cadmium / analysis,  pharmacology*
Carbon Isotopes
Electric Stimulation
Guinea Pigs
Histamine H1 Antagonists / pharmacology
Ileum / analysis,  drug effects*
Methacholine Compounds / antagonists & inhibitors
Muscle Contraction / drug effects*
Muscle, Smooth / drug effects
Potassium / antagonists & inhibitors
Sorbitol / analysis
Zinc / analysis,  pharmacology*
Zinc Isotopes
Reg. No./Substance:
0/Carbon Isotopes; 0/Histamine H1 Antagonists; 0/Methacholine Compounds; 0/Radioisotopes; 0/Zinc Isotopes; 50-70-4/Sorbitol; 7440-09-7/Potassium; 7440-43-9/Cadmium; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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