Document Detail

Spasmolytic effect of Petroselinum crispum (Parsley) on rat's ileum at different calcium chloride concentrations.
MedLine Citation:
PMID:  19090276     Owner:  NLM     Status:  MEDLINE    
Traditional herbal medicines such as Petroselinum crispum (Parsley) have been used for treatment of intestinal disorders in Iran. To date no pharmacological evidence for their effectiveness has been reported. The aim of this study was to examine the relaxant effect of hydroalcoholic extract of Petroselinum crispum on isolated adult male Wistar rat's ileum contraction by KCl 60 (mM). The extract was prepared from parsley seed with 80% ethanol. A portion of ileum was removed and placed in an organ bath containing Tyrode solution (37 degrees C, pH = 7.4) bubbled with air. From a resting tension of 1 g, isotonic Transducer and Harvard Universal Oscillograph were used for recording contraction of ileum after administration of 60 mM KCl. Various concentration of extract were added to the bath. This experiment showed that, the extract in a dose-dependent manner decreased the induced-KCl ileums contraction (n = 7, p < 0.001). Also adding extract before influence of KCl, cause reduced effect of KCl (n = 7, p < 0.001). In addition, the Tyrode solution without CaCl2 and high concentration of K+, various concentration of extract significantly (n = 7, p < 0.001) decreased the CaCl2-induced contraction. Therefore, it seems that the relaxation effect of extract alcoholic parsley seed on the contraction of ileum is performed by blocking of voltage-gated calcium channels.
A A Moazedi; D N Mirzaie; S M Seyyednejad; M R Zadkarami; A Amirzargar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pakistan journal of biological sciences: PJBS     Volume:  10     ISSN:  1028-8880     ISO Abbreviation:  Pak. J. Biol. Sci.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2008-12-18     Completed Date:  2009-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101247723     Medline TA:  Pak J Biol Sci     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  4036-42     Citation Subset:  IM    
Department of Biology, School of Science, Shahid Chamran University, Ahwaz, Iran.
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MeSH Terms
Calcium Chloride / pharmacology*
Dose-Response Relationship, Drug
Hydrogen-Ion Concentration
Ileum / drug effects*
Parasympatholytics / pharmacology
Petroselinum / metabolism*
Plant Extracts / pharmacology*
Potassium Chloride
Rats, Wistar
Reg. No./Substance:
0/Parasympatholytics; 0/Plant Extracts; 10043-52-4/Calcium Chloride; 7447-40-7/Potassium Chloride

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