Document Detail

Sparing and recovery of spatial alternation performance after entorhinal cortex lesions in rats.
MedLine Citation:
PMID:  6477719     Owner:  NLM     Status:  MEDLINE    
Groups of adult rats were first trained on a spatial alternation task and then subjected to unilateral entorhinal cortex lesions, unilateral entorhinal cortex lesions followed by dorsal psalterium transections, or bilateral entorhinal cortex lesions. After this surgery, the rats were then tested for retention of spatial alternation. Neither unilateral lesions alone nor unilateral lesions followed by dorsal psalterium transections resulted in long-term spatial performance deficits; however, animals with bilateral lesions exhibited severe impairments from which they eventually recovered. The results from animals with bilateral entorhinal damage indicate that extensive postoperative training may facilitate the recovery of spatial alternation performance. Histological analyses indicated that the crossed entorhinal projection proliferated in the dentate gyrus after unilateral entorhinal lesions and such anomalous growth occurred independently of any changes in alternation performance.
J J Ramirez; D G Stein
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Behavioural brain research     Volume:  13     ISSN:  0166-4328     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-11-19     Completed Date:  1984-11-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  53-61     Citation Subset:  IM; S    
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MeSH Terms
Brain Mapping
Learning / physiology
Limbic System / injuries,  physiology*,  physiopathology
Psychomotor Performance / physiology*
Retention (Psychology) / physiology
Space Perception / physiology*
Grant Support
R01 AG00295-03/AG/NIA NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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