Document Detail

The Spanish school of neurology and the first American cases of Alzheimer's disease.
MedLine Citation:
PMID:  15069873     Owner:  NLM     Status:  MEDLINE    
The object of this review is to recapitulate historical events tied to the discovery of Alzheimer's disease and to narrate the contribution by two graduates of the Spanish School of Neurology, N. Achúcarro and G. Lafora, who went on to describe the first cases in North America. Both Achúcarro and Lafora had studied with Alois Alzheimer at his Nervenklinik in Munich, Germany. Subsequently, their scientific skills were put to work at the neuropathology laboratory at the Government Hospital for the Insane in Washington, D.C. Achúcarro described the first American case of this disease in a 77-year-old patients in 1910. All the descriptions were accompanied by new findings, such as granular degeneration. This was the sixth case recorded in the literature worldwide. One year later, in 1911, Lafora presented a third case, a 62-year-old Civil War veteran, and subsequently a fifth case, a 50-year-old woman, in 1914. In this case Lafora observed histological structures similar to Lewy bodies. These original contributions have not been sufficiently mentioned in writings dealing with the history of Alzheimer's disease.
E García-Albea; J M Pérez Trullen
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Publication Detail:
Type:  Biography; Historical Article; Journal Article; Portraits    
Journal Detail:
Title:  Journal of the history of the neurosciences     Volume:  12     ISSN:  0964-704X     ISO Abbreviation:  J Hist Neurosci     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-04-08     Completed Date:  2004-05-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9441330     Medline TA:  J Hist Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  437-45     Citation Subset:  IM; Q    
Department of Neurology, University Hospital Príncipe de Asturias, Alcalá University, Alcalá de Henares, Madrid, Spain.
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MeSH Terms
Alzheimer Disease / history*,  pathology
History, 20th Century
Neurology / history*
North America
Personal Name Subject
Personal Name Subject:
Nicholás Achúcarro Lund; Gonzalo Rodríguez Lafora

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