Document Detail


Spaceflight effects on beta-adrenoceptor and metabolic properties in rat plantaris.
MedLine Citation:
PMID:  8828657     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effects of 14 days of spaceflight on beta-adrenoceptor (beta-AR), mitochondrial enzyme activities, and fiber type composition were studied in plantaris muscles of male adult Sprague-Dawley rats. The beta-AR was analyzed in cross sections by quantitative autoradiography. The maximum binding capacity (Bmax) of beta-AR was significantly lowered (approximately 29%) after flight, but the recovery was not completed within 9 days in 1-G environment. Because the dissociation constant remained unchanged, it is suggested that the changes in the Bmax were caused by the alteration of receptor number. The activities of succinate dehydrogenase (SDH) measured in whole homogenates were subnormal (approximately -24%) in muscles sampled approximately 5 h after flight but they were normalized during 9 days of recovery. The percent composition of fiber types and beta-hydroxyacyl CoA dehydrogenase (HAD) activity did not change significantly due to spaceflight. It is suggested that the spaceflight-induced decrease of the Bmax of beta-AR in plantaris was accompanied by a lowered activity of a mitochondrial inner-membrane enzyme SDH but not a matrix enzyme HAD.
Authors:
Y Ohira; W Yasui; F Kariya; T Tanaka; I Kitajima; I Maruyama; S Nagaoka; C Sekiguchi; W E Hinds
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  81     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-12-18     Completed Date:  1996-12-18     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  152-5     Citation Subset:  IM; S    
Affiliation:
Department of Physiology and Biomechanics, National Institute of Fitness and Sports, Kanoya City, Japan.
Space Flight Mission:
Flight Experiment; STS-58 Shuttle Project; manned; short duration
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MeSH Terms
Descriptor/Qualifier:
3-Hydroxyacyl CoA Dehydrogenases / metabolism
Adaptation, Physiological / physiology
Animals
Autoradiography
Body Weight / physiology
Histocytochemistry
Iodine Radioisotopes / diagnostic use
Kinetics
Male
Mitochondria, Muscle / enzymology,  metabolism
Muscle Fibers, Skeletal / metabolism
Muscle, Skeletal / cytology,  metabolism*
Organ Size / physiology
Rats
Rats, Sprague-Dawley
Receptors, Adrenergic, beta / metabolism*
Space Flight*
Succinate Dehydrogenase / metabolism
Chemical
Reg. No./Substance:
0/Iodine Radioisotopes; 0/Receptors, Adrenergic, beta; EC 1.1.1.35/3-Hydroxyacyl CoA Dehydrogenases; EC 1.3.99.1/Succinate Dehydrogenase

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