| Soystatin (VAWWMY), a novel bile acid-binding peptide, decreased micellar solubility and inhibited cholesterol absorption in rats. | |
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MedLine Citation:
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PMID: 20699550 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to identify a novel peptide derived from soybean protein that induces inhibition of cholesterol absorption in vivo. VAWWMY (Val-Ala-Trp-Trp-Met-Tyr, designated soystatin) had a significantly greater ability to bind bile acid than soybean protein peptic hydrolysate (SPH) or casein tryptic hydrolysate (CTH). Surprisingly, the bile-acid binding ability of VAWWMY was almost as strong as that of the hypocholesterolemic medicine cholestyramine. The micellar solubility of cholesterol was significantly lower in the presence of VAWWMY than in that of SPH or CTH. We found that soystatin derived from soybean glycinin acted as an inhibitor of cholesterol absorption in vivo. |
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Authors:
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Satoshi Nagaoka; Atsushi Nakamura; Haruhiko Shibata; Yoshihiro Kanamaru |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-07 |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: 74 ISSN: 1347-6947 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-08-25 Completed Date: 2010-12-15 Revised Date: 2010-12-28 |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: Japan |
Other Details:
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Languages: eng Pagination: 1738-41 Citation Subset: IM |
Affiliation:
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Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan. nagaoka@gifu-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption
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drug effects Amino Acid Sequence Animals Bile Acids and Salts / metabolism* Cholesterol / chemistry, metabolism* Male Micelles* Oligopeptides / chemistry, metabolism*, pharmacology* Rats Solubility / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Micelles; 0/Oligopeptides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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