| Soy protein and isoflavones influence adiposity and development of metabolic syndrome in the obese male ZDF rat. | |
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MedLine Citation:
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PMID: 17356265 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Previously, we demonstrated that soy protein ameliorates the diabetic phenotype in several rodent models of obesity and metabolic syndrome (MS). This study was designed to further elucidate factors related to adiposity, glycemic control, and renal function in male Zucker Diabetic Fatty (ZDF/Lepr(fa)) rats. METHODS: Animals were randomly assigned to one of four diets: control, casein (C); low isoflavone (LIS) soy protein; high isoflavone (HIS) soy protein, or casein + rosiglitazone (CR) for 11 weeks. At sacrifice, physiological, biochemical, and molecular parameters were determined. RESULTS: Body weight and total adiposity were higher in LIS and CR diet groups despite lower food intake. Additionally, these animals exhibited differential regulation of adipose-specific proteins (PPAR-gamma and GLUT4) and enzyme activity (FAS and GPDH). HIS-fed animals had reduced total and liver adiposity. Glycemic control was prolonged in both soy-based and rosiglitazone (RGZ) groups. Renal dysfunction was significantly reduced in soy-fed and RGZ-treated rodents as demonstrated by lower levels of proteinuria and dilated tubules with proteinaceous casts. CONCLUSION: Collectively, these data provide evidence that soy protein with low or high isoflavone content may have therapeutic significance in reducing severity of diabetes, MS, and renal disease as demonstrated in this preclinical model. |
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Authors:
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Jeremy Davis; Allan Higginbotham; Timothy O'Connor; Naima Moustaid-Moussa; Adam Tebbe; Young-Cheul Kim; Kae Won Cho; Neil Shay; Stuart Adler; Richard Peterson; William Banz |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-14 |
Journal Detail:
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Title: Annals of nutrition & metabolism Volume: 51 ISSN: 1421-9697 ISO Abbreviation: Ann. Nutr. Metab. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-04-23 Completed Date: 2007-05-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8105511 Medline TA: Ann Nutr Metab Country: Switzerland |
Other Details:
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Languages: eng Pagination: 42-52 Citation Subset: IM |
Copyright Information:
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Copyright 2007 S. Karger AG, Basel. |
Affiliation:
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Southern Illinois University, Carbondale, IL 62901-4317, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity
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drug effects* Animals Blood Glucose / drug effects Caseins / pharmacology Hypoglycemic Agents / pharmacology Isoflavones / pharmacology* Kidney Diseases / prevention & control Liver / drug effects Male Metabolic Syndrome X / diet therapy*, etiology Milk Proteins / pharmacology Obesity / complications* Proteinuria / prevention & control Rats Rats, Inbred Strains Soybean Proteins / administration & dosage* Thiazolidinediones / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Caseins; 0/Hypoglycemic Agents; 0/Isoflavones; 0/Milk Proteins; 0/Soybean Proteins; 0/Thiazolidinediones; 122320-73-4/rosiglitazone |
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