Document Detail


Soy protein diet ameliorates renal nitrotyrosine formation and chronic nephropathy induced by puromycin aminonucleoside.
MedLine Citation:
PMID:  14672755     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been shown that reactive oxygen species are involved in chronic puromycin aminonucleoside (PAN) induced nephrotic syndrome (NS) and that a 20% soy protein diet reduces renal damage in this experimental model. The purpose of the present work was to investigate if a 20% soy protein diet is able to modulate kidney nitrotyrosine formation and the activity of renal antioxidant enzymes (catalase, glutathione peroxidase, Cu,Zn- or Mn-superoxide dismutase) which could explain, at least in part, the protective effect of the soy protein diet in rats with chronic NS induced by PAN. Four groups of rats were studied: (1) Control rats fed 20% casein diet, (2) Nephrotic rats fed 20% casein diet, (3) Control rats fed 20% soy protein diet, and (4) Nephrotic rats fed 20% soy protein diet. Chronic NS was induced by repeated injections of PAN and rats were sacrificed at week nine. The soy protein diet ameliorated proteinuria, hypercholesterolemia, and the increase in serum creatinine and blood urea nitrogen observed in nephrotic rats fed 20% casein diet. Kidney nitrotyrosine formation increased in nephrotic rats fed 20% casein diet and this increase was ameliorated in nephrotic rats fed 20% soy protein diet. However, the soy protein diet was unable to modulate the antioxidant enzymes activities in control and nephrotic rats fed 20% soy protein diet. Food intake was similar in the two diet groups. The protective effect of a 20% soy protein diet on renal damage in chronic nephropathy induced by PAN was associated with the amelioration in the renal nitrotyrosine formation but not with the modulation of antioxidant enzymes.
Authors:
José Pedraza-Chaverrí; Diana Barrera; Rogelio Hernández-Pando; Omar N Medina-Campos; Cristino Cruz; Fernanda Murguía; César Juárez-Nicolás; Ricardo Correa-Rotter; Nimbe Torres; Armando R Tovar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  74     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-15     Completed Date:  2004-02-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  987-99     Citation Subset:  IM    
Affiliation:
Department of Biology, Faculty of Chemistry, Universidad Nacional Autónoma de México (UNAM), 04510, D.F., México, Mexico
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MeSH Terms
Descriptor/Qualifier:
Animals
Antimetabolites / toxicity*
Antioxidants / metabolism
Blood Urea Nitrogen
Body Weight / drug effects
Catalase / metabolism
Cholesterol / blood
Creatinine / blood
Diet
Eating / drug effects
Glutathione Peroxidase / metabolism
Immunohistochemistry
Kidney / drug effects,  metabolism*,  pathology
Kidney Failure, Chronic / chemically induced*,  pathology,  prevention & control*
Kidney Function Tests
Lipids / blood
Male
Proteinuria / chemically induced,  metabolism
Puromycin Aminonucleoside / toxicity*
Rats
Rats, Wistar
Soybean Proteins / pharmacology*
Soybeans / chemistry*
Superoxide Dismutase / metabolism
Tyrosine / analogs & derivatives*,  metabolism*
Chemical
Reg. No./Substance:
0/Antimetabolites; 0/Antioxidants; 0/Lipids; 0/Soybean Proteins; 3604-79-3/3-nitrotyrosine; 55520-40-6/Tyrosine; 57-88-5/Cholesterol; 58-60-6/Puromycin Aminonucleoside; 60-27-5/Creatinine; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase

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